Regulation of novelty seeking by midbrain dopamine D2/D3 signaling and ghrelin is altered in obesity.
Regulation of novelty seeking by midbrain dopamine D2/D3 signaling and ghrelin is altered in obesity.
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中脑多巴胺D2/D3信号传导和生长素蛋白的新颖性调节在肥胖症中发生了改变。
DOI：
10.1002/oby.20690
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发表时间：
2014-06
期刊：
影响因子：
6.9
通讯作者：
Dunn, Julia P.
中科院分区：
文献类型：
--
作者：
Savage, Shane W.;Zald, David H.;Cowan, Ronald L.;Volkow, Nora D.;Marks-Shulman, Pamela A.;Kessler, Robert M.;Abumrad, Naji N.;Dunn, Julia P.
探讨正常体重和肥胖女性的新奇寻求特质与中脑多巴胺受体和酰基ghrelin水平的关系。NS预测成瘾行为，并假设有助于饮食行为。在健康人中，NS与黑质（SN）中的DA受体呈负相关。我们推测肥胖会影响DA信号和AG对NS的调节。我们使用PET扫描测量SN中DA 2/3型受体（D2/D3 R）结合电位（BPND）。被试完成了三维人格问卷（TPQ-NS）和AG测量。8例NW和19例肥胖者（BMI分别为22和38 kg/m2），TPQ-NS（16和15）和SND 2/D3 R BPND（2.48和2.66）相似，AG（256和60）较高（p<0.01）。在NW中，D2/D3 R BPND和TPQ-NS呈负相关（r=-0.7），但在肥胖中则无相关性（p>0.10）。NW组AG与TPQ-NS呈正相关（r=0.9），肥胖组AG与TPQ-NS无相关性（p>0.10）。在NW中，D2 R BPND和AG呈负相关（r=-0.8），但在肥胖中呈正相关（r=0.6）。肥胖者不维持NS与中脑D2/D3 R可用性或NW中存在的AG的假定调节关系。对于NW和肥胖，SN D2/D3 R可用性和AG之间也存在相反的关系。NS在肥胖中的调节改变需要进一步探索。
To investigate the relationship of novelty seeking traits (NS) with midbrain dopamine (DA) receptors and acyl ghrelin levels (AG) in normal weight (NW) and obese females. NS predict addictive behaviors and are hypothesized to contribute to eating behaviors. In healthy, NS are negatively associated with DA receptors in the substantia nigra (SN). We hypothesized that obesity would influence the regulation of NS by DA signaling and AG. We used PET scanning to measure DA type 2/type 3 receptor (D2/D3R) binding potential (BPND) in the SN. Participants completed Tridimensional Personality Questionnaire-Novelty-Seeking Scale (TPQ-NS) and AG were measured. In 8 NW and 19 obese (BMI 22 vs 38 kg/m2), TPQ-NS (16 vs15) and SN D2/D3R BPND (2.48vs2.66) were similar, while AG higher (256vs60, p<0.01), respectively. D2/D3R BPND and TPQ-NS had a negative relationship in NW (r=−0.7) but not in obese (p>0.10). AG and TPQ-NS were positively correlated in NW (r=0.9) but not in obese (p>0.10). D2R BPND and AG were negatively correlated in NW (r=−0.8) but positively in obese (r=0.6). Obese do not maintain posited regulatory relationships for NS to either midbrain D2/D3R availability or AG present in NW. Also opposite relationships exist for NW and obese between SN D2/D3R availability and AG. The altered regulation of NS in obesity needs to be further explored.
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影响因子：
25
作者：
Buckholtz, Joshua W.;Treadway, Michael T.;Cowan, Ronald L.;Woodward, Neil D.;Benning, Stephen D.;Li, Rui;Ansari, M. Sib;Baldwin, Ronald M.;Schwartzman, Ashley N.;Shelby, Evan S.;Smith, Clarence E.;Cole, David;Kessler, Robert M.;Zald, David H.
通讯作者：
Zald, David H.
影响因子：
15.9
作者：
Abizaid, Alfonso;Liu, Zhong-Wu;Horvath, Tamas L.
通讯作者：
Horvath, Tamas L.
影响因子：
2.5
作者：
Kim, Yonjung;Park, Myoung Kyu;Chung, Sungkwon
通讯作者：
Chung, Sungkwon
DOI：
10.1097/00004647-199601000-00005
发表时间：
1996-01-01
影响因子：
6.3
作者：
Lammertsma, AA;Bench, CJ;Frackowiak, RSJ
通讯作者：
Frackowiak, RSJ
影响因子：
3.4
作者：
Jerlhag, Elisabet;Egecioglu, Emil;Engel, Jorgen A.
通讯作者：
Engel, Jorgen A.