Perturbation-induced high-frequency pulsing of nano-ESI with facile ion selection at atmospheric pressure.
Perturbation-induced high-frequency pulsing of nano-ESI with facile ion selection at atmospheric pressure.
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大气压下具有简易离子选择的纳米ESI的扰动诱导高频脉冲。
DOI：
10.1039/d0an01198c
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发表时间：
2020-11-09
期刊：
影响因子：
--
通讯作者：
Jorabchi K
中科院分区：
文献类型：
--
作者：
McMahon WP ;Jorabchi K
纳米ESI是一种常用的电离技术，具有不断扩大的分析优势。在这里，我们报告了一种对纳米ESI进行高频(500-3800赫兹)脉冲的简便方法，提供了高通量的迁移率选择离子。脉冲是通过对放置在纳米ESI发射器下游1厘米处的电极进行相对较低的电压调制(80V峰间)来完成的，该电极偏置于恒定电位。将电极配置为离子门可以通过扫描调制频率来实现基于迁移率的离子选择。我们的研究表明，电极调制扰动了连续的纳米ESI，导致溶液在喷雾脉冲之间的发射极尖端积累。离子的选择性传输发生在与基频的谐波相对应的频率上，该基频由每个离子从发射器到离子门(脉冲电极)的传播时间确定。值得注意的是，以这种方式选择的离子在各次谐波中的强度是相似的，这表明分析物的电离效率与发射极尖端的累积体积几乎没有关系。此外，使用这种技术的离子迁移率选择分析物的强度达到了没有离子选择的连续纳米ESI的50%，强调了通过高频脉冲产生高效的离子。这些发现表明了脉冲纳米电喷雾离子检测器在增强分析效用方面的潜力，例如在大气压下的高通量选择试剂离子供应器，并为进一步提高纳米电喷雾离子检测器的分析性能开辟了新的途径。一种新的纳米ESI脉冲系统允许选择离子，与连续喷涂相比，离子通量损失最小。
Nano-ESI is a commonly used ionization technique with continually expanding analytical advantages. Here, we report a facile way for high-frequency (500–3800 Hz) pulsing of nano-ESI, providing a high flux of mobility-selected ions. The pulsing is accomplished using a relatively low-voltage modulation (80 V peak-to-peak) of an electrode placed < 1 cm downstream of a nano-ESI emitter biased to a constant potential. Configuring the electrode as an ion gate enables mobility-based ion selection by scanning the modulation frequency. Our investigations indicate that the electrode modulation perturbs continuous nano-ESI, resulting in solution accumulation at the emitter tip between spray pulses. Selective transmission of ions occurs at frequencies corresponding to harmonics of a fundamental frequency determined by the travel time of each ion from the emitter to the ion gate (pulsing electrode). Remarkably, the intensities of ions selected in this fashion are similar across the harmonics, suggesting that the ionization efficiencies of analytes have minimal dependence on the accumulated volume at the emitter tip. Moreover, intensities of ion-mobility-selected analytes using this technique reach > 50% of those in continuous nano-ESI without ion selection, underscoring efficient ion generation via high-frequency pulsing. These findings indicate the potential of the pulsed nano-ESI for enhanced analytical utility, such as a high-flux selected-reagent-ion supplier at atmospheric pressure, and chart new avenues to further enhance the analytical performance of nano-ESI. A new nano-ESI pulsing regime allows selection of ions with minimal loss of ion flux compared to continuous spray.
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DOI：
10.1007/s13361-013-0749-z
发表时间：
2014-01
影响因子：
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