Thyroid Hormones and Timing of Pubertal Onset in a Longitudinal Cohort of Females, Northern California, 2006-11.
Thyroid Hormones and Timing of Pubertal Onset in a Longitudinal Cohort of Females, Northern California, 2006-11.
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甲状腺激素和纵向女性队列中青春期开始的时间，北加州，2006-11。
DOI：
10.1111/ppe.12280
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发表时间：
2016
影响因子：
2.8
通讯作者：
Windham,GayleC
中科院分区：
文献类型：
--
作者：
Wilken,JasonA;Greenspan,LouiseC;Kushi,LawrenceH;Voss,RobertW;Windham,GayleC
青春期的时间是由一个复杂的相互作用的激素调节。很少有研究评价甲状腺激素在青春期开始中的作用。我们调查了血液中游离和总甲状腺素（FT 4，TT 4），游离三碘甲状腺原氨酸，促甲状腺激素和青春期发病之间的关联females.MethodsParticipants包括323凯萨永久北方加州成员在2004年至2011年期间，谁提供了血液样本，在第一个3年的研究。在每个参与者的第一份血液样本中测量血清中的甲状腺激素浓度。青春期开始定义为乳房（乳房初长）和阴毛（阴毛初长）发育的坦纳分期≥2。甲状腺激素和青春期发病之间的关联进行了评估多变量logistic回归和考克斯比例风险modelling.ResultsAt抽血，参与者的年龄为6.5-10.1（中位数7.7）年，10%已达到乳房初长，12%已达到阴毛初长。受试者在抽血后随访0-5年（中位数4）。在最近一次临床访视中，参与者年龄为6.7-14.7岁（中位数12.3），92%达到乳房初长，89%达到阴毛初长。在抽血时达到乳房初长或阴毛初长与甲状腺激素之间没有发现任何关联。纵向检查，较高浓度的青春期前FT 4和TT 4与较早的青春期初潮相关（调整后的风险比（HR）1.41，95%置信区间（CI）1.06，1.86;每ng/dL和aHR 1.07，95% CI 1.02，1.12;每μg/dL分别）。
BackgroundPubertal timing is regulated by a complex interplay of hormones. Few studies have evaluated the role of thyroid hormones in pubertal onset. We investigated the associations between blood concentrations of free and total thyroxine (FT4, TT4), free triiodothyronine, and thyroid stimulating hormone and pubertal onset among females.MethodsParticipants included 323 Kaiser Permanente Northern California members followed at annual intervals during 2004–11, who provided a blood sample during the first 3 years of the study. Thyroid hormone concentrations were measured in serum in the first blood specimen available for each participant. Pubertal onset was defined as Tanner stage ≥2 for breast (thelarche) and pubic hair (pubarche) development. Associations between thyroid hormones and pubertal onset were assessed by multivariable logistic regression and Cox proportional hazards modelling.ResultsAt blood draw, participants were age 6.5–10.1 (median 7.7) years, 10% had reached thelarche, and 12% had reached pubarche. Participants were followed 0–5 years after blood draw (median 4). At most recent clinical visit, participants were age 6.7–14.7 (median 12.3) years, 92% had reached thelarche, and 89% had reached pubarche. No associations were identified between having reached thelarche or pubarche at time of blood draw and thyroid hormones. Examined longitudinally, higher concentrations of pre‐pubertal FT4 and TT4 were associated with earlier pubarche (adjusted hazard ratio (HR) 1.41, 95% confidence interval (CI) 1.06, 1.86; per ng/dL and aHR 1.07, 95% CI 1.02, 1.12; per μg/dL respectively).ConclusionsHigher pre‐pubertal concentrations of FT4 and TT4 are associated with earlier pubarche.
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青春期躯体发育
DOI：
--
发表时间：
1976
期刊：
影响因子：
--
作者：
J. Taranger;I. Engström;H. Lichtenstein;I. Svennberg‐Redegren
通讯作者：
I. Svennberg‐Redegren
影响因子：
9.3
作者：
David Zurakowski;James Di Canzio;J. A. Majzoub
通讯作者：
David Zurakowski;James Di Canzio;J. A. Majzoub
影响因子：
--
作者：
Herman-Giddens, ME
通讯作者：
Herman-Giddens, ME
正常受试者血清 TSH 和甲状腺激素的昼夜节律和 30 分钟变化。
DOI：
10.1530/acta.0.0890659
发表时间：
1978
期刊：
Acta endocrinologica
影响因子：
--
作者：
J. Weeke;H. Gundersen
通讯作者：
H. Gundersen
溴化阻燃剂和其他持久性有机卤化化合物的身体负担及其对美国女孩的描述。
影响因子：
8.3
作者：
Windham,GayleC;Pinney,SusanM;Sjodin,Andreas;Lum,Raymond;Jones,RichardS;Needham,LarryL;Biro,FrankM;Hiatt,RobertA;Kushi,LawrenceH
通讯作者：
Kushi,LawrenceH