Association study between dopamine D3 receptor gene variant and personality traits
Association study between dopamine D3 receptor gene variant and personality traits
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多巴胺D3受体基因变异与人格特质的关联研究
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
H. Bergman
中科院分区：
文献类型：
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作者：
E. Jönsson;E. Burgert;M. Crocq;J. Gustavsson;K. Forslund;M. Mattila‐Evenden;G. Rylander;L. Flyckt;L. Bjerkenstedt;F. Wiesel;M. Åsberg;H. Bergman
多巴胺受体基因变异被假设影响以新奇寻求和相关特征为特征的人格特质。我们分析了多巴胺D3受体基因（DRD 3）变异的瑞典人口（n = 373）调查的一个或多个几个人格问卷。DRD 3基因型与15种Karolinska人格量表（KSP）和5种健康相关人格5因素量表（HP 5i）中的任何一种都没有显着关系。DRD 3变体与一些与新奇寻求相关的量表相关：瑞典大学的人格量表（SSP）冒险寻求和修订的NEO人格量表（NEO-PI-R）幻想（O 1）和秩序（C2）量表。也与气质和性格量表（TCI）合作性和同情心（C4）量表有关。然而，经过多重检验校正后，没有显著差异。我们的结论是，调查DRD 3多态性不会有重大影响，在调查人群的个性。© 2003 Wiley利斯公司
Dopamine receptor gene variation has been hypothesized to influence personality traits characterized by novelty seeking and related traits. We analyzed a dopamine D3 receptor gene (DRD3) variant in a Swedish population (n = 373) investigated with one or more of several personality questionnaires. No significant relationships were found between DRD3 genotypes and any of the 15 Karolinska Scales of Personality (KSP) and five Health‐relevant Personality 5 factor inventory (HP5i) scales. The DRD3 variant was associated with some scales related to novelty seeking: the Swedish universities Scales of Personality (SSP) Adventure Seeking and the revised NEO personality inventory (NEO‐PI‐R) Fantasy (O1) and Order (C2) scales. There were also associations with the Temperament and Character Inventory (TCI) Cooperativeness and Compassion (C4) scales. After correction for multiple testing, however, no significant difference remained. We conclude that the investigated DRD3 polymorphism does not have a major impact on personality in the investigated population. © 2003 Wiley‐Liss, Inc.
影响因子：
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作者：
CLONINGER, CR;SVRAKIC, DM;PRZYBECK, TR
通讯作者：
PRZYBECK, TR