Improving sensitivity to eye gaze cues in autism using serious game technology: study protocol for a phase I randomised controlled trial.
Improving sensitivity to eye gaze cues in autism using serious game technology: study protocol for a phase I randomised controlled trial.
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DOI：
10.1136/bmjopen-2018-023682
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发表时间：
2018-10-04
期刊：
影响因子：
2.9
通讯作者：
Smyth JM
中科院分区：
文献类型：
--
作者：
Scherf KS;Griffin JW;Judy B;Whyte EM;Geier CF;Elbich D;Smyth JM
自闭症谱系障碍（ASD）的特点是社会沟通障碍。核心症状是社交行为的缺陷，包括对面部的视觉注意力有限和对眼睛凝视线索的敏感性。我们设计了一个干预游戏，使用严重的游戏机制，为青少年与ASD。它旨在训练ASD患者发现眼睛，特别是凝视的转移，提供有关外部世界的信息。我们预测，游戏将增加对凝视线索的理解和对面孔的关注。自闭症青少年社交游戏（佐贺）试验是一项初步的随机对照试验，比较了干预游戏与等待控制条件。基线评估后，将随机分配34名患有ASD的青少年（10-18岁），其全量表智商在70 - 130之间，最低二年级阅读水平，及其父母（干预或对照条件相同）。干预参与者将被指示在家里的电脑上玩电脑游戏约30分钟，每周三次。所有家庭在基线和随机化后约2个月在实验室中进行所有测量。主要结果评估与眼动追踪，以衡量眼睛凝视线索和社会视觉关注的脸的敏感性;次要结果评估与问卷调查，以衡量社交技能和自闭症样行为。分析将侧重于评估干预措施的可行性、安全性和初步有效性。佐贺由宾夕法尼亚州立大学州立大学的机构审查委员会批准（00005097）。研究结果将通过科学会议和同行评审期刊传播，并通过通讯向参与者传播。在收集到全部数据后，如果分析表明干预游戏有效，则将向处于控制条件下的家庭提供。NCT02968225。
Autism spectrum disorder (ASD) is characterised by impairments in social communication. Core symptoms are deficits in social looking behaviours, including limited visual attention to faces and sensitivity to eye gaze cues. We designed an intervention game using serious game mechanics for adolescents with ASD. It is designed to train individuals with ASD to discover that the eyes, and shifts in gaze specifically, provide information about the external world. We predict that the game will increase understanding of gaze cues and attention to faces. The Social Games for Adolescents with Autism (SAGA) trial is a preliminary, randomised controlled trial comparing the intervention game with a waitlist control condition. 34 adolescents (10–18 years) with ASD with a Full-Scale IQ between 70 and 130 and a minimum second grade reading level, and their parents, will be randomly assigned (equally to intervention or the control condition) following baseline assessments. Intervention participants will be instructed to play the computer game at home on a computer for ~30 min, three times a week. All families are tested in the lab at baseline and approximately 2 months following randomisation in all measures. Primary outcomes are assessed with eye tracking to measure sensitivity to eye gaze cues and social visual attention to faces; secondary outcomes are assessed with questionnaires to measure social skills and autism-like behaviours. The analyses will focus on evaluating the feasibility, safety and preliminary effectiveness of the intervention. SAGA is approved by the Institutional Review Board at Pennsylvania State University (00005097). Findings will be disseminated via scientific conferences and peer-reviewed journals and to participants via newsletter. The intervention game will be available to families in the control condition after the full data are collected and if analyses indicate that it is effective. NCT02968225.
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