Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy.
Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy.
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DOI：
10.7150/thno/v01p0240
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发表时间：
2011-04-13
期刊：
影响因子：
12.4
通讯作者：
Cui D
中科院分区：
文献类型：
--
作者：
Huang P;Xu C;Lin J;Wang C;Wang X;Zhang C;Zhou X;Guo S;Cui D
光动力疗法(PDT)是一种治疗癌症和非癌症疾病的非侵入性治疗方法，它通过癌细胞摄取光敏剂(PSS)，然后进行照射。利用纳米材料作为PSS的载体，是促进光动力疗法在临床医学中发展的一条非常有前途的途径。本研究设计并制备了一种新型的叶酸偶联氧化石墨烯(GO)作为靶向给药系统，以获得更高的特异性。通过疏水相互作用和π-π堆积，有效地将第二代光敏剂(PS)三氯乙烷(Ce6)负载到体系中。该纳米载体可显著增加Ce6在肿瘤细胞中的蓄积，对MGC803细胞具有显著的光动力效应。提示叶酸偶联GO-Ce6作为靶向PDT的药物载体具有很大的潜力。
Photodynamic therapy (PDT) has emerged as an alternative and promising noninvasive treatment for cancer as well as non-cancer diseases, which involves the uptake of photosensitizers (PSs) by cancer cells followed by irradiation. The use of nanomaterials as carriers of PSs is a very promising approach to improve the development of PDT in clinical medicine. In this study, a novel folic acid-conjugated graphene oxide (GO) was strategically designed and prepared as targeting drug delivery system to achieve higher specificity. The second generation photosensitizer (PS) Chlorin e6 (Ce6) was effectively loaded into the system via hydrophobic interactions and π-π stacking. The nanocarriers can significantly increase the accumulation of Ce6 in tumor cells and lead to a remarkable photodynamic efficacy on MGC803 cells upon irradiation. These suggested that folic acid-conjugated GO loaded Ce6 had great potential as effective drug delivery system in targeting PDT.
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