Nicotine enhances modulation of food‐cue reactivity by leptin and ghrelin in the ventromedial prefrontal cortex
Nicotine enhances modulation of food‐cue reactivity by leptin and ghrelin in the ventromedial prefrontal cortex
复制标题
尼古丁增强腹内侧前额皮质中瘦素和生长素释放肽对食物线索反应性的调节
DOI：
10.1111/adb.12167
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发表时间：
2015
影响因子：
3.4
通讯作者：
Smolka
中科院分区：
文献类型：
--
作者：
Kroemer;Wuttig;Bidlingmaier;Zimmermann;Smolka
Endocrine signals such as ghrelin and leptin are known to modulate the mesocorticolimbic dopaminergic system and, consequently, show associations with food and drug reward. In animal models, nicotine was demonstrated to reduce body weight by attenuating food intake and effects of leptin and ghrelin are partly modulated by nicotinic acetylcholine receptors which hint at potential interactions. However, the neuropharmacological modulation of endocrine signals by nicotine in healthy humans remains to be tested experimentally. We used functional magnetic resonance imaging to investigate food‐cue reactivity after an overnight fast and following a caloric load (oral glucose tolerance test, OGTT) in 26 healthy normal‐weight never‐smokers. Moreover, we administered either nicotine (2 mg) or placebo gums using a randomized cross‐over design and assessed blood plasma levels of ghrelin and leptin. During fasting, nicotine administration decreased correlations with ghrelin levels in the mesocorticolimbic system whereas correlations with leptin were increased. After the OGTT, nicotine increased the modulatory effects of ghrelin and leptin on food‐cue reactivity, particularly in the ventromedial prefrontal cortex (vmPFC) and the amygdala. Critically, this led to an indirect modulation of the behavioral ‘appetizer effect’ (i.e. cue‐induced increases in subjective appetite) by homeostatic feedback signals via food‐cue reactivity in vmPFC. We conclude that nicotine enhances the effect of ghrelin and leptin in the valuation and relevance network which might, in turn, reduce appetite. This highlights that amplifying the impact of homeostatic signals such as ghrelin and leptin in normal‐weight individuals might hint at a mechanism contributing to nicotine's anorexic potential.
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DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
蒋毅;杜永成;许建英
通讯作者：
许建英
影响因子：
4.8
作者：
Kroemer, Nils B.;Krebs, Lena;Smolka, Michael N.
通讯作者：
Smolka, Michael N.
二十四小时瘦素水平对累积的短期能量失衡做出反应并预测随后的摄入量。
DOI：
10.1210/jcem.85.8.6755
发表时间：
2000
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Chin-Chance,C;Polonsky,KS;Schoeller,DA
通讯作者：
Schoeller,DA
影响因子：
7.7
作者：
Cummings, DE;Purnell, JQ;Weigle, DS
通讯作者：
Weigle, DS
影响因子：
4.9
作者：
Adam, C. L.;Findlay, P. A.
通讯作者：
Findlay, P. A.