Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing.
Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing.
复制标题
DOI：
10.1038/ncomms3081
复制
发表时间：
2013
影响因子：
16.6
通讯作者：
Riley, Paul R.
中科院分区：
文献类型：
--
作者：
Evans, Mark A.;Smart, Nicola;Dube, Karina N.;Bollini, Sveva;Clark, James E.;Evans, Hayley G.;Taams, Leonie S.;Richardson, Rebecca;Levesque, Mathieu;Martin, Paul;Mills, Kevin;Riegler, Johannes;Price, Anthony N.;Lythgoe, Mark F.;Riley, Paul R.
The downstream consequences of inflammation in the adult mammalian heart are formation of a non-functional scar, pathological remodelling and heart failure. In zebrafish, hydrogen peroxide (H2O2) released from a wound is the initial instructive chemotactic cue for the infiltration of inflammatory cells, however, the identity of a subsequent resolution signal(s), to attenuate chronic inflammation, remains unknown. Here we reveal that Thymosin β4-Sulfoxide inhibits interferon-γ, and increases monocyte dispersal and cell death, lies downstream of H2O2 in the wounded fish and triggers depletion of inflammatory macrophages at the injury site. This function is conserved in the mouse and observed after cardiac injury, where it promotes wound healing and reduced scarring. In human T cell/CD14+ monocyte co-cultures, Tβ4-SO inhibits IFN-γ and increases monocyte dispersal and cell death, likely by stimulating superoxide production. Thus, Tβ4-SO is a putative target for therapeutic modulation of the immune response, resolution of fibrosis and cardiac repair.
登录
查看更多内容
影响因子：
4.9
作者：
Rasoul, S;Carretero, OA;Rhaleb, NE
通讯作者：
Rhaleb, NE
DOI：
10.1073/pnas.0308215100
发表时间：
2004-02-03
影响因子：
11.1
作者：
Yermolaieva, O;Xu, R;Hoshi, T
通讯作者：
Hoshi, T
影响因子：
7.2
作者：
Simon, HU;Haj-Yehia, A;Levi-Schaffer, F
通讯作者：
Levi-Schaffer, F
影响因子：
5.5
作者：
ROTHE, G;VALET, G
通讯作者：
VALET, G
影响因子：
37.8
作者：
Frangogiannis, NG;Lindsey, ML;Entman, ML
通讯作者：
Entman, ML