Ventral prefrontal cortex and emotion regulation in aging: A case for utilizing transcranial magnetic stimulation.

Ventral prefrontal cortex and emotion regulation in aging: A case for utilizing transcranial magnetic stimulation.
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DOI:
10.1002/gps.4982
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发表时间:
2019-03
影响因子:
4
通讯作者:
Zald DH
Zald DH
中科院分区:
医学2区
文献类型:
--
作者:
Kim JU;Weisenbach SL;Zald DH

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腹外侧前额叶皮层(ventrolateral prefrontal cortex,vlPFC)在情感因素影响人类认知的复杂过程中发挥着重要作用。从人类神经影像学研究中积累的证据,结合对病变患者和动物模型的研究,阐明了vlPFC在情绪调节(ER)中的作用。本综述旨在讨论和整合最近的研究结果相关的vlPFC的作用,在ER的背景下,老化,从不同的来源,并建议未来的研究方向,利用经颅磁刺激(TMS)。我们总结了现有文献中调查额叶介导ER的神经基础的结果,然后突出了最近直接比较健康的年轻人和老年人群体的研究的主要结果。最后,我们指出未解决的问题,值得在未来的研究。我们提出了未来的研究方向,利用TMS来回答关键的未解决的问题。此外,我们还讨论了使用TMS作为ER中现有神经影像学方法的补充的潜在优势、挑战和局限性。
The ventrolateral prefrontal cortex (vlPFC) has been speculated to play an important role in complex processes that allow emotional factors to influence human cognition. Accumulating evidence from human neuroimaging studies, in conjunction with studies of patients with lesions and animal models shed light on the role of the vlPFC in emotion regulation (ER). This review aims to discuss and integrate recent findings related to vlPFC’s role in ER in the context of aging, drawing from diverse sources, and suggest future directions for research utilizing Transcranial Magnetic Stimulation (TMS). We summarize findings from the existing literature investigating the neural basis of frontal-lobe mediated ER and then highlight major findings from recent studies directly comparing healthy younger and older adult groups. We conclude by pointing to unaddressed questions worth pursuing in future research. We propose future research directions utilizing TMS to answer key unaddressed questions. Moreover, we discuss the potential advantages, challenges, and limitations of using TMS as a complement to the existing neuroimaging methods in ER.
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