Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis.
Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis.
复制标题
HIF 在结直肠癌中的预后价值和临床病理学差异：来自荟萃分析的证据
DOI：
10.1371/journal.pone.0080337
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Huang J
中科院分区：
文献类型：
--
作者：
Chen Z;He X;Xia W;Huang Q;Zhang Z;Ye J;Ni C;Wu P;Wu D;Xu J;Qiu F;Huang J
大量研究评估了HIF在结直肠癌中的预后价值，但结论不确定。同时，近年来有关HIF-1α和HIF-2α在临床病理学上的差异性研究较少。使用相同的检索策略在PubMed和Web of Science数据库中检索相关文献。分析HIF在结直肠癌中的临床病理差异及预后意义。共有23项研究（包括2984例CRC患者）符合纳入标准。结果表明，HIF高表达与总生存期（HR 2.06，95%CI 1.55-2.74）和无病生存期（HR 2.84，95%CI 1.87-4.31）显著相关。亚组分析显示，HIF-1α和HIF-2α过表达均与预后不良相关。合并HR为2.01（95% CI：1.55-2.6）和2.07（95% CI：1.01-4.26）。根据研究地点、患者数量、质量评分和临界值对HIF-1α进行进一步亚组分析。结果显示，HIF-1α过表达与低OS显著相关，特别是在亚洲国家（HR 2.3，95%CI：1.74-3.01），而在欧洲或其他国家则无相关性。此外，HIF-1α的过度表达与临床病理特征（包括Dukes分期）密切相关（OR 0.39，95% CI：0.17-0.89），UICC分期（OR 0.42 95% CI：0.3-0.59），浸润深度（OR 0.71，95% CI：0.51-0.99）、淋巴结状态（OR 0.49，95% CI：0.32-0.73）和转移（OR 0.29，95% CI：0.11-0.81）。而HIF-2α过表达仅与肿瘤分化程度相关（OR 0.48，95% CI：0.29-0.81）。本研究表明HIF-1α和HIF-2α过表达均与不良预后相关。在亚洲国家，HIF-1α过表达似乎与预后不良有关。此外，HIF-1α和HIF-2α表达具有明显的临床病理特征。
The prognostic value of HIFs in colorectal cancer was evaluated in a large number of studies, but the conclusions were inconclusive. Meanwhile, clinicopathologic differences of HIF-1α and HIF-2α were rarely compared in recent studies. Identical search strategies were used to search relevant literatures in the PubMed and Web of Science databases. The prognostic significances and clinicopathological differences of HIFs in CRC were analyzed. A total of 23studies comprising 2984 CRC patients met the inclusion criteria. The results indicated that overexpressed HIFs were significantly associated with increase of mortality risk, including overall survival (OS) (HR 2.06 95%CI 1.55–2.74) and disease free survival (HR 2.84, 95%CI 1.87–4.31). Subgroup analysis revealed that both overexpressed HIF-1α and HIF-2α had correlations with worse prognosis. The pooled HRs were 2.01 (95% CI: 1.55–2.6) and 2.07(95% CI: 1.01–4.26). Further subgroup analysis on HIF-1α was performed by study location, number of patients, quality score and cut-off value. The results showed that HIF-1α overexpression was significantly associated with poor OS, particularly in Asian countries (HR 2.3, 95% CI: 1.74–3.01), while not in European or other countries. In addition, overexpression of HIF-1α was closely related with these clinicopathological features, including Dukes' stages (OR 0.39, 95% CI: 0.17–0.89), UICC stages (OR 0.42 95% CI: 0.3–0.59), depth of invasion (OR 0.71, 95% CI: 0.51–0.99), lymphnode status (OR 0.49, 95% CI: 0.32–0.73) and metastasis (OR 0.29, 95% CI: 0.11–0.81). While overexpression of HIF-2α was only associated with grade of differentiation (OR 0.48, 95% CI: 0.29–0.81). This study showed that both HIF-1α and HIF-2α overexpression were associated with an unfavorable prognosis. HIF-1α overexpression seemed to be associated with worse prognosis in Asian countries. Additionally, HIF-1α and HIF-2α indicated distinct clinicopathologic features.
登录
查看更多内容
影响因子：
254.7
作者：
Siegel, Rebecca;Naishadham, Deepa;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin
影响因子：
5.7
作者：
HOCKEL, M;KNOOP, C;VAUPEL, P
通讯作者：
VAUPEL, P
影响因子：
6
作者：
Baba, Yoshifumi;Nosho, Katsuhiko;Ogino, Shuji
通讯作者：
Ogino, Shuji
影响因子：
3.8
作者：
Rajaganeshan, R.;Prasad, R.;Jayne, D. G.
通讯作者：
Jayne, D. G.
影响因子：
8.8
作者：
Griffiths, E A;Pritchard, S A;Valentine, H R;Whitchelo, N;Bishop, P W;Ebert, M P;Price, P M;Welch, I M;West, C M L
通讯作者：
West, C M L