Atrial natriuretic peptide and atrial pressure in patients with congestive heart failure.
Atrial natriuretic peptide and atrial pressure in patients with congestive heart failure.
复制标题
充血性心力衰竭患者心房钠尿肽和心房压。
DOI：
--
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发表时间：
1986
影响因子：
158.5
通讯作者：
F. Bühler
中科院分区：
文献类型：
--
作者：
A. Raine;P. Erne;E. Bürgisser;F. Müller;P. Bolli;F. Burkart;F. Bühler
为了确定心房压力和房利钠肽释放之间的关系，我们测量了26例心脏病患者的血浆肽浓度，其中11例心房压力正常，15例心房压力升高（其中11例双心房压力升高）。与60名健康对照（48 +/- 14 vs 17 +/- 2 pmol / l）相比，11名心脏疾病和房压正常的患者外周静脉血中平均肽水平（+/- SEM）增加。在房压升高的患者中，外周静脉、右心房、肺动脉和全身动脉血浆中的肽浓度比正常房压患者增加了两倍。静脉血浆与右心房血浆之间肽浓度升高（P < 0.002），肺动脉血浆与全身动脉血浆之间肽浓度升高（P < 0.01），提示肽从心房释放。右房压与右房肽浓度呈线性相关（r = 0.835, P < 0.001），肺楔压与全身动脉肽浓度呈线性相关（r = 0.866, P < 0.001）。9例患者右心房压和肽浓度均随运动试验升高。我们的结论是，房利钠肽的释放至少部分受到左右心房压力的调节。区分两个心房的相对贡献和确定肽释放在心力衰竭发病机制中的作用将需要进一步的研究。
To define the relation between atrial pressures and the release of atrial natriuretic peptide, we measured plasma concentrations of the peptide in 26 patients with cardiac disease--11 with normal atrial pressures and 15 with elevated atrial pressures (11 of these 15 had elevated pressures in both atria). Mean peptide levels (+/- SEM) in the peripheral venous blood were increased in the 11 patients with cardiac disease and normal atrial pressures, as compared with 60 healthy controls (48 +/- 14 vs. 17 +/- 2 pmol per liter). In the patients with elevated atrial pressures, peptide concentrations were increased twofold in peripheral venous, right atrial, pulmonary arterial, and systemic arterial plasma, as compared with the concentrations in the patients with normal atrial pressures. A step-up in peptide concentration was seen between the venous and right atrial plasma (P less than 0.002) and between the pulmonary and systemic arterial plasma (P less than 0.01), suggesting release of the peptide from the atria. A linear relation was found between right atrial pressure and right atrial peptide concentration (r = 0.835, P less than 0.001) and between pulmonary wedge pressure and the systemic arterial peptide concentration (r = 0.866, P less than 0.001). Right atrial pressure and the peptide concentration both increased with exercise testing in the nine patients evaluated. We conclude that the release of atrial natriuretic peptide is at least partly regulated by right and left atrial pressures. Distinguishing the relative contributions of the two atria and defining the role of peptide release in the pathogenesis of heart failure will require further investigation.
大鼠下丘脑、心房和血浆中的心房钠尿因子：通过特异性放射免疫测定法测定。
DOI：
10.1016/0006-291x(84)91606-1
发表时间：
1984
影响因子：
3.1
作者：
Tanaka,I;Misono,KS;Inagami,T
通讯作者：
Inagami,T