Diurnal salivary cortisol is associated with body mass index and waist circumference: the Multiethnic Study of Atherosclerosis.
Diurnal salivary cortisol is associated with body mass index and waist circumference: the Multiethnic Study of Atherosclerosis.
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DOI：
10.1002/oby.20047
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发表时间：
2013-01
期刊：
影响因子：
6.9
通讯作者：
Golden, Sherita Hill
中科院分区：
文献类型：
--
作者：
Champaneri, Shivam;Xu, Xiaoqiang;Carnethon, Mercedes R.;Bertoni, Alain G.;Seeman, Teresa;DeSantis, Amy S.;Roux, Ana Diez;Shrager, Sandi;Golden, Sherita Hill
神经内分泌异常，如下丘脑-垂体-肾上腺（HPA）轴的激活，与肥胖有关;然而，很少有大规模的人群为基础的研究检查HPA轴和肥胖的标志物。我们研究了皮质醇觉醒反应（CAR）和昼夜唾液皮质醇曲线与肥胖的横截面关联。多种族动脉粥样硬化研究（梅萨）压力研究包括1,002名白色、西班牙裔和黑人男性和女性（平均年龄65±9.8岁），他们在3天内收集了多达18份唾液皮质醇样本。使用回归样条模型对皮质醇曲线进行建模，该模型结合了受试者特异性效应的随机参数。皮质醇曲线测量包括唤醒皮质醇、CAR（唤醒至唤醒后30分钟）、早期下降（唤醒后30分钟至2小时）、晚期下降（唤醒后2小时至就寝时间）和相应的曲线下面积（AUC）。体重指数（BMI）和腰围（WC）用于估计肥胖。对于整个队列，BMI和WC均与觉醒皮质醇（p<0.05）、觉醒上升和早期下降期间的AUC呈负相关，并在调整年龄、种族/民族、性别、糖尿病状态、社会经济状况、β受体阻滞剂、类固醇、激素替代疗法和吸烟状况后与早期下降斜率呈正相关（p<0.05）。未观察到性别、年龄和人种/种族的效应异质性。较高的BMI和WC与神经内分泌失调相关，这在大样本人群中存在，仅部分由其他协变量解释。
Neuroendocrine abnormalities, such as activation of the hypothalamic-pituitary-adrenal (HPA) axis, are associated with obesity; however, few large-scale population-based studies have examined HPA axis and markers of obesity. We examined the cross-sectional association of the cortisol awakening response (CAR) and diurnal salivary cortisol curve with obesity. The Multi-Ethnic Study of Atherosclerosis (MESA) Stress Study includes 1,002 White, Hispanic, and Black men and women (mean age 65±9.8 years) who collected up to 18 salivary cortisol samples over 3 days. Cortisol profiles were modeled using regression spline models that incorporated random parameters for subject-specific effects. Cortisol curve measures included awakening cortisol, CAR (awakening to 30 minutes post-awakening), early decline (30 minutes to 2 hours post-awakening), late decline (2 hours post-awakening to bedtime), and the corresponding areas under the curve (AUC). Body-mass-index (BMI) and waist circumference (WC) were used to estimate adiposity. For the entire cohort, both BMI and WC were negatively correlated with awakening cortisol (p<0.05), AUC during awakening rise and early decline and positively correlated to the early decline slope (p<0.05) after adjustments for age, race/ethnicity, gender, diabetes status, socioeconomic status, beta blockers, steroids, hormone replacement therapy and smoking status. No heterogeneities of effects were observed by gender, age, and race/ethnicity. Higher BMI and WC are associated with neuroendocrine dysregulation, which is present in a large population sample, and only partially explained by other covariates.
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DOI：
10.1152/ajpendo.90769.2008
发表时间：
2009-02-01
影响因子：
5.1
作者：
Purnell, Jonathan Q.;Kahn, Steven E.;Brunzell, John D.
通讯作者：
Brunzell, John D.
影响因子：
3.5
作者：
Björntorp, P;Holm, G;Rosmond, R
通讯作者：
Rosmond, R
影响因子：
5.8
作者：
Kumari, Meena;Chandola, Tarani;Kivimaki, Mika
通讯作者：
Kivimaki, Mika
影响因子：
3.3
作者：
Epel, ES;McEwen, B;Ickovics, JR
通讯作者：
Ickovics, JR
影响因子：
5.8
作者：
PASQUALI, R;CANTOBELLI, S;BARBARA, L
通讯作者：
BARBARA, L