Burden of hospitalized childhood community-acquired pneumonia: A retrospective cross-sectional study in Vietnam, Malaysia, Indonesia and the Republic of Korea.
Burden of hospitalized childhood community-acquired pneumonia: A retrospective cross-sectional study in Vietnam, Malaysia, Indonesia and the Republic of Korea.
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DOI：
10.1080/21645515.2017.1375073
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发表时间：
2018-01-02
影响因子：
4.8
通讯作者：
Meyer N
中科院分区：
文献类型：
--
作者：
Tan KK;Dang DA;Kim KH;Kartasasmita C;Kim HM;Zhang XH;Shafi F;Yu TW;Ledesma E;Meyer N
背景：很少有研究描述亚洲儿童的社区获得性肺炎 (CAP) 负担。我们估计了韩国（高收入）、印度尼西亚、马来西亚（中等收入）和越南（低/中等收入）九家医院儿童中所有 CAP 住院治疗的比例。方法：在一年或两年的时间内，使用 ICD-10 出院代码识别因 CAP 住院的 5 岁以下儿童。病例与肺炎球菌结合疫苗功效研究 (COMPAS) 中使用的疑似 (S-CAP)、确诊 (C-CAP) 或细菌 CAP (B-CAP) 的标准化定义相匹配。计算了 CAP 相关住院的直接医疗费用中位数。结果：越南（三个中心）：5 岁以下儿童全因住院的 7591 例 CAP 发作中，4.3%（95% 置信区间 4.2;4.4）为 S-CAP，3.3%（3.2;3.4）为 C-CAP，1.4%（1.3;1.4）为 B-CAP。 B-CAP 病死率 (CFR) 为 1.3%。马来西亚（两个中心）：1027 例 CAP 发作，占 2.7% (2.6;2.9)； 2.6% (2.4;2.8); 0.04% (0.04;0.1) 分别归因于 S-CAP、C-CAP 和 B-CAP。一名患有 B-CAP 的儿童死亡。印度尼西亚（1 个中心）：960 例 CAP 发作，占 18.0% (17.0;19.1)； 16.8% (15.8;17.9); 0.3% (0.2;0.4) 分别归因于 S-CAP、C-CAP 和 B-CAP。 B-CAP CFR 为 20%。韩国（三个中心）：3151 例 CAP 发作，占 21.1%（20.4；21.7）； 11.8%（11.2；12.3）； 2.4% (2.1;2.7) 分别归因于 S-CAP、C-CAP 和 B-CAP。没有死亡。费用：B-CAP 发作时与 CAP 相关的住院费用最高：每次 145.00 美元（越南）至 1013.3 美元（韩国）。结论：CAP 住院治疗在所有四个研究国家中造成了重要的健康和费用负担 (NMRR-12-50-10793)。
Background: Few studies describe the community-acquired pneumonia (CAP) burden in children in Asia. We estimated the proportion of all CAP hospitalizations in children from nine hospitals across the Republic of Korea (high-income), Indonesia, Malaysia (middle-income), and Vietnam (low/middle-income). Methods: Over a one or two-year period, children <5 years hospitalized with CAP were identified using ICD-10 discharge codes. Cases were matched to standardized definitions of suspected (S-CAP), confirmed (C-CAP), or bacterial CAP (B-CAP) used in a pneumococcal conjugate vaccine efficacy study (COMPAS). Median total direct medical costs of CAP-related hospitalizations were calculated. Results: Vietnam (three centers): 7591 CAP episodes were identified with 4.3% (95% confidence interval 4.2;4.4) S-CAP, 3.3% (3.2;3.4) C-CAP and 1.4% (1.3;1.4) B-CAP episodes of all-cause hospitalization in children aged <5 years. The B-CAP case fatality rate (CFR) was 1.3%. Malaysia (two centers): 1027 CAP episodes were identified with 2.7% (2.6;2.9); 2.6% (2.4;2.8); 0.04% (0.04;0.1) due to S-CAP, C-CAP, and B-CAP, respectively. One child with B-CAP died. Indonesia (one center): 960 CAP episodes identified with 18.0% (17.0;19.1); 16.8% (15.8;17.9); 0.3% (0.2;0.4) due to S-CAP, C-CAP, and B-CAP, respectively. The B-CAP CFR was 20%. Korea (three centers): 3151 CAP episodes were identified with 21.1% (20.4;21.7); 11.8% (11.2;12.3); 2.4% (2.1;2.7) due to S-CAP, C-CAP, and B-CAP, respectively. There were no deaths. Costs: CAP-related hospitalization costs were highest for B-CAP episodes: 145.00 (Vietnam) to 1013.3 USD (Korea) per episode. Conclusion: CAP hospitalization causes an important health and cost burden in all four countries studied (NMRR-12-50-10793).
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168.9
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Bhutta, Zulfiqar A.;Das, Jai K.;Black, Robert E.
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