The relationship between the neuromodulator adenosine and behavioral symptoms of autism.
The relationship between the neuromodulator adenosine and behavioral symptoms of autism.
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DOI：
10.1016/j.neulet.2011.06.007
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发表时间：
2011-08-01
影响因子：
2.5
通讯作者：
Eigsti IM
中科院分区：
文献类型：
--
作者：
Masino SA;Kawamura M Jr;Plotkin LM;Svedova J;DiMario FJ Jr;Eigsti IM
神经调节剂腺苷是一种内源性睡眠促进剂，神经保护剂和抗惊厥剂，自闭症患者经常遭受睡眠中断和/或癫痫发作。我们假设增加腺苷可以减少自闭症的行为症状，并且根据已发表的研究，特定的生理刺激预计会增加大脑腺苷。为了测试腺苷和自闭症之间的关系，我们开发了一个定制的基于父母的问卷，以评估儿童参与预计会影响腺苷的活动，并量化这些经历后的行为变化。父母对研究假设很天真，所有条件都是预先分配的。结果表明，与预先建立的事件相关的行为明显更好，预测增加而不是减少或对腺苷没有影响。了解腺苷和自闭症之间的生理关系可以开辟新的治疗策略-可能预防癫痫发作，改善睡眠，减少社交和行为功能障碍。
The neuromodulator adenosine is an endogenous sleep promoter, neuroprotector and anticonvulsant, and people with autism often suffer from sleep disruption and/or seizures. We hypothesized that increasing adenosine can decrease behavioral symptoms of autism, and, based on published research, specific physiological stimuli are expected to increase brain adenosine. To test the relationship between adenosine and autism, we developed a customized parent-based questionnaire to assess child participation in activities expected to influence adenosine and quantify behavioral changes following these experiences. Parents were naive to study hypotheses and all conditions were pre-assigned. Results demonstrate significantly better behavior associated with events pre-established as predicted to increase rather than decrease or have no influence on adenosine. Understanding the physiological relationship between adenosine and autism could open new therapeutic strategies - potentially preventing seizures, improving sleep, and reducing social and behavioral dysfunction.
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