The aryl hydrocarbon receptor as a moderator of host-microbiota communication.
The aryl hydrocarbon receptor as a moderator of host-microbiota communication.
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DOI：
10.1016/j.cotox.2017.02.001
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发表时间：
2017-03
影响因子：
4.6
通讯作者：
Patterson AD
中科院分区：
文献类型：
--
作者：
Zhang L;Nichols RG;Patterson AD
芳香烃受体（AHR）是宿主-微生物群通讯网络的重要组成部分。野生型和无Ahr小鼠的比较以及来自使用有效AHR配体（例如，2，3，7，8-四氯二苯并-对-二恶英）提供了令人信服的证据，证明AHR可能是宿主-微生物群相互作用的主要调节剂，从而有助于塑造免疫系统并影响宿主代谢。代谢组学和基于测序的微生物群落分析是最近的两项技术进步，有助于巩固这种宿主-微生物群信号传导概念，不仅确定了宿主和微生物群产生的特定配体如何激活AHR，而且确定了AHR的激活/破坏如何影响和塑造微生物群。我们刚刚开始了解AHR配体的时间性质和组织和微生物群特异性产生如何促进许多AHR依赖性过程。在这篇综述中，我们重点介绍了几个最新进展，其中代谢组学和微生物群结构和功能的表征产生了新的视角，通过这些视角来评估AHR活性。
The aryl hydrocarbon receptor (AHR) is an important component of the host-microbiota communication network. Comparisons of wild-type and Ahr-null mice as well as from exposure studies with potent AHR ligands (e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin) have provided compelling evidence that the AHR may be a master regulator of the host-microbiota interaction thus helping to shape the immune system and impact host metabolism. Metabolomics and sequenced-based microbial community profiling, two recent technological advances, have helped to solidify this host-microbiota signaling concept and identified not only how specific ligands generated by the host and by the microbiota can activate the AHR, but also how activation/disruption of the AHR can influence and shape the microbiota. We are just beginning to understand how the temporal nature and tissue- and microbiota-specific generation of AHR ligands contribute to many AHR-dependent processes. In this review, we focus on several recent advances where metabolomics and characterization of the microbiota structure and function have generated new perspectives by which to evaluate AHR activity.
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