CD8(+) Resident Memory T Cells and Viral Infection.
CD8(+) Resident Memory T Cells and Viral Infection.
复制标题
CD8( ) 驻留记忆 T 细胞和病毒感染。
DOI：
10.3389/fimmu.2018.02093
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发表时间：
2018
影响因子：
7.3
通讯作者：
Xu F
中科院分区：
文献类型：
--
作者：
Wu X;Wu P;Shen Y;Jiang X;Xu F
Tissue-resident memory T (Trm) cells are a subset of recently identified memory T cells that mainly reside and serve as sentinels in non-lymphoid peripheral tissues. Unlike the well-characterized circulating central memory T (Tcm) cells and effector memory T (Tem) cells, Trm cells persist in the tissues, do not recirculate into blood, and offer immediate protection against pathogens upon reinfection. In this review, we focus on CD8+ Trm cells and briefly introduce their characteristics, development, maintenance, and function during viral infection. We also discuss some unresolved problems, such as how CD8+ Trm cells adapt to the local tissue microenvironment, how Trm cells interact with other immune cells during their development and maintenance, and the mechanisms by which CD8+ Trm cells confer immune protection. We believe that a better understanding of these problems is of great clinical and therapeutic value and may contribute to more effective vaccination and treatments against viral infection.
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影响因子：
32.4
作者：
Herndler-Brandstetter D;Ishigame H;Shinnakasu R;Plajer V;Stecher C;Zhao J;Lietzenmayer M;Kroehling L;Takumi A;Kometani K;Inoue T;Kluger Y;Kaech SM;Kurosaki T;Okada T;Flavell RA
通讯作者：
Flavell RA
影响因子：
82.9
作者：
Adachi T;Kobayashi T;Sugihara E;Yamada T;Ikuta K;Pittaluga S;Saya H;Amagai M;Nagao K
通讯作者：
Nagao K
影响因子：
32.4
作者：
Iborra, Salvador;Martinez-Lopez, Maria;Khouili, Sofia C.;Enamorado, Michel;Cueto, Francisco J.;Conde-Garrosa, Ruth;del Fresno, Carlos;Sancho, David
通讯作者：
Sancho, David
影响因子：
15.9
作者：
Boddupalli, Chandra Sekhar;Nair, Shiny;Dhodapkar, Madhav V.
通讯作者：
Dhodapkar, Madhav V.
影响因子：
64.8
作者：
Jiang, Xiaodong;Clark, Rachael A.;Liu, Luzheng;Wagers, Amy J.;Fuhlbrigge, Robert C.;Kupper, Thomas S.
通讯作者：
Kupper, Thomas S.