Autophagy in alcohol-induced liver diseases.
Autophagy in alcohol-induced liver diseases.
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DOI：
10.1111/j.1530-0277.2012.01742.x
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Donohue TM Jr
中科院分区：
文献类型：
--
作者：
Dolganiuc A;Thomes PG;Ding WX;Lemasters JJ;Donohue TM Jr
酒精是世界上滥用最多的物质，也是肝损伤的重要来源;酒精引起的肝病的机制尚未完全了解。酒精暴露的肝细胞中发生显著的细胞毒性和蛋白质合成和降解的损伤，沿着能量平衡的变化和对病原体的反应的改变。自噬是细胞通过溶酶体依赖性机制进行的自我吞噬过程，维持蛋白质合成、降解和自我再循环之间的平衡。自噬是正常稳态的一部分，它可以由威胁细胞完整性的多种因素触发，包括饥饿，毒素或病原体。多种因素调节自噬;以折叠不充分的蛋白质和受损的高能量产生细胞内细胞器为代价的细胞完整性的存活和保存是病理条件下自噬的突出目标。巧合的是，不充分折叠的蛋白质积累和高能量产生的细胞内细胞器，如线粒体，被酒精滥用损害;这些酒精诱导的病理学发现促使研究自噬在酒精诱导的肝损伤的发病机制中的作用。本文综述了自噬在酒精性肝病中的作用和意义。
Alcohol is the most abused substance worldwide and a significant source of liver injury; the mechanisms of alcohol-induced liver disease are not fully understood. Significant cellular toxicity and impairment of protein synthesis and degradation occur in alcohol-exposed liver cells, along with changes in energy balance and modified responses to pathogens. Autophagy is the process of cellular catabolism through the lysosomal-dependent machinery, which maintains a balance among protein synthesis, degradation, and recycling of self. Autophagy is part of normal homeostasis and it can be triggered by multiple factors that threaten cell integrity including starvation, toxins, or pathogens. Multiple factors regulate autophagy; survival and preservation of cellular integrity at the expense of inadequately-folded proteins and damaged high energy-generating intracellular organelles are prominent targets of autophagy in pathologic conditions. Coincidentally, inadequately-folded proteins accumulate and high energy-generating intracellular organelles, such as mitochondria, are damaged by alcohol abuse; these alcohol-induced pathological findings prompted investigation of the role of autophagy in the pathogenesis of alcohol-induced liver damage. Our review summarizes the current knowledge about the role and implications of autophagy in alcohol-induced liver disease.
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DOI：
10.1002/hep.22470
发表时间：
2008-10
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Hritz I;Mandrekar P;Velayudham A;Catalano D;Dolganiuc A;Kodys K;Kurt-Jones E;Szabo G
通讯作者：
Szabo G
影响因子：
4.8
作者：
Ding, Wen-Xing;Ni, Hong-Min;Yin, Xiao-Ming
通讯作者：
Yin, Xiao-Ming
影响因子：
56.9
作者：
BARAONA, E;LEO, MA;LIEBER, CS
通讯作者：
LIEBER, CS
DOI：
10.1258/ebm.2011.010360
发表时间：
2011-05-01
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
--
作者：
Ding WX;Manley S;Ni HM
通讯作者：
Ni HM
影响因子：
29.4
作者：
Ding WX;Li M;Chen X;Ni HM;Lin CW;Gao W;Lu B;Stolz DB;Clemens DL;Yin XM
通讯作者：
Yin XM