Prenatal and postnatal polycyclic aromatic hydrocarbon exposure, airway hyperreactivity, and Beta-2 adrenergic receptor function in sensitized mouse offspring.
Prenatal and postnatal polycyclic aromatic hydrocarbon exposure, airway hyperreactivity, and Beta-2 adrenergic receptor function in sensitized mouse offspring.
复制标题
DOI：
10.1155/2013/603581
复制
发表时间：
2013
影响因子：
2.9
通讯作者：
Miller RL
中科院分区：
文献类型：
--
作者：
Chu S;Zhang H;Maher C;McDonald JD;Zhang X;Ho SM;Yan B;Chillrud S;Perera F;Factor P;Miller RL
Despite data associating exposure to traffic-related polycyclic aromatic hydrocarbons (PAH) in asthma, mechanistic support has been limited. We hypothesized that both prenatal and early postnatal exposure to PAH would increase airway hyperreactivity (AHR) and that the resulting AHR may be insensitive to treatment with a β 2AR agonist drug, procaterol. Further, we hypothesized that these exposures would be associated with altered β 2AR gene expression and DNA methylation in mouse lungs. Mice were exposed prenatally or postnatally to a nebulized PAH mixture versus negative control aerosol 5 days a week. Double knockout β 2AR mice were exposed postnatally only. Prenatal exposure to PAH was associated with reduced β 2AR gene expression among nonsensitized mice offspring, but not increases in DNA methylation or AHR. Postnatal exposure to PAH was borderline associated with increased AHR among sensitized wildtype, but not knockout mice. In the first study that delivers PAH aerosols to mice in a relatively physiological manner, small effects on AHR and β 2AR gene expression, but not β 2AR agonist drug activity, were observed. If confirmed, the results may suggest that exposure to PAH, common ambient urban pollutants, affects β 2AR function, although the impact on the efficacy of β 2AR agonist drugs used in treating asthma remains uncertain.
登录
查看更多内容
影响因子：
3.6
作者：
Patel MM;Miller RL
通讯作者：
Miller RL
影响因子：
5.9
作者：
McCormack, Meredith C.;Breysse, Patrick N.;Matsui, Elizabeth C.;Hansel, Nadia N.;Peng, Roger D.;Curtin-Brosnan, Jean;Williams, D'Ann L.;Wills-Karp, Marsha;Diette, Gregory B.
通讯作者：
Diette, Gregory B.
影响因子：
14.2
作者：
Ege, MJ;Bieli, C;Braun-Fahrländer, C
通讯作者：
Braun-Fahrländer, C
DOI：
10.1164/rccm.200509-1405oc
发表时间：
2006-11-15
影响因子：
24.7
作者：
Hawkins, Gregory A.;Tantisira, Kelan;Bleecker, Eugene R.
通讯作者：
Bleecker, Eugene R.
DOI：
10.1164/ajrccm.162.1.9907092
发表时间：
2000-07-01
影响因子：
24.7
作者：
Israel, E;Drazen, JM;Yandava, CN
通讯作者：
Yandava, CN