Interindividual variability of electric fields during transcranial temporal interference stimulation (tTIS).
Interindividual variability of electric fields during transcranial temporal interference stimulation (tTIS).
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DOI：
10.1038/s41598-021-99749-0
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发表时间：
2021-10-13
影响因子：
4.6
通讯作者：
Herrmann CS
中科院分区：
文献类型：
--
作者：
von Conta J;Kasten FH;Ćurčić-Blake B;Aleman A;Thielscher A;Herrmann CS
经颅颞叶干扰刺激（tTIS）是一种新型的非侵入性脑电刺激技术，用于深度电刺激神经元。大脑深部区域通常较小，因此需要精确定位。由相同的tTIS蒙太奇引起的个体受试者之间电场的可变性迄今为止尚不清楚，这可能是精确定位tTIS的主要关注点。因此，本研究的目的是调查25个受试者中由于tTIS引起的电场变异性。为此，模拟了由两个中心频率不同的电极对组成的不同电极蒙太奇的电场，以便用tTIS瞄准选定的感兴趣区域（roi）。此外，我们还将tTIS的电场与传统tac的电场进行了比较。后者也是基于两个电极对，然而，这是在一个共同的频率驱动相。结果表明，在单受试者水平上，tTIS过程中ROIs（左海马区、左运动区和丘脑）内部的电场强度是不同的。此外，与tACS相比，tTIS的刺激更集中，靠近刺激电极的皮质区域的共刺激要弱得多。然而，两种方法的ROI内部电场是可比较的。总的来说，我们的结果强调了tTIS在刺激深层目标方面的潜在优势，而不是传统的tACS。然而，它们也表明需要个性化的刺激蒙太奇来充分利用这种方法的潜力。
Transcranial temporal interference stimulation (tTIS) is a novel non-invasive brain stimulation technique for electrical stimulation of neurons at depth. Deep brain regions are generally small in size, making precise targeting a necessity. The variability of electric fields across individual subjects resulting from the same tTIS montages is unknown so far and may be of major concern for precise tTIS targeting. Therefore, the aim of the current study is to investigate the variability of the electric fields due to tTIS across 25 subjects. To this end, the electric fields of different electrode montages consisting of two electrode pairs with different center frequencies were simulated in order to target selected regions-of-interest (ROIs) with tTIS. Moreover, we set out to compare the electric fields of tTIS with the electric fields of conventional tACS. The latter were also based on two electrode pairs, which, however, were driven in phase at a common frequency. Our results showed that the electric field strengths inside the ROIs (left hippocampus, left motor area and thalamus) during tTIS are variable on single subject level. In addition, tTIS stimulates more focally as compared to tACS with much weaker co-stimulation of cortical areas close to the stimulation electrodes. Electric fields inside the ROI were, however, comparable for both methods. Overall, our results emphasize the potential benefits of tTIS for the stimulation of deep targets, over conventional tACS. However, they also indicate a need for individualized stimulation montages to leverage the method to its fullest potential.
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