Targeting alpha-band oscillations in a cortical model with amplitude-modulated high-frequency transcranial electric stimulation.
Targeting alpha-band oscillations in a cortical model with amplitude-modulated high-frequency transcranial electric stimulation.
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DOI：
10.1016/j.neuroimage.2018.02.005
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发表时间：
2018-06
期刊：
影响因子：
5.7
通讯作者：
Fröhlich F
中科院分区：
文献类型：
--
作者：
Negahbani E;Kasten FH;Herrmann CS;Fröhlich F
针对特定网络活动模式的非侵入性脑刺激，如经颅交流电刺激(Tacs)，已成为了解神经元振荡在认知和行为中的因果作用的重要工具。然而，传统的正弦TAC限制了记录刺激时神经元活动的能力，并且缺乏空间焦点。一种特别有希望的新Tacs刺激范例使用幅度调制(AM)高频波形(AM-Tacs)，其具有可以克服这些限制的慢信号包络。更有甚者。当以相同的电流强度(例如1-2 mA)施加时，使用高频载波信号的AM-TAC比传统TAC更耐受，例如在皮肤刺激性和磷烯发生方面。然而，AM-Tacs波形参与神经元靶点活动的基本机制仍不清楚。我们使用大脑皮层的计算模型来研究AM-TAC如何调制内源性振荡，并将目标参与机制与传统(未调制)低频TAC的情况进行了比较。对刺激幅度和强度的分析表明，皮层振荡被锁定在AM刺激信号的包络上，因此表现出与常规(未调制)低频TAC相同的目标交战机制。然而，在计算模型中，AM-TAC需要比低频(未调制)TAC波形更高的电流强度来实现明显的相位同步。我们对载波频率的分析表明，在高频载波的使用和成功携带所需的刺激幅度之间可能存在权衡。总之，我们的计算模拟支持使用慢包络高频载波AM波形作为非侵入性调制大脑振荡的工具。需要更多的实验数据来确定最佳刺激参数，并评估AM-TAC和传统TAC的耐受性和安全性。
Non-invasive brain stimulation to target specific network activity patterns, e.g. transcranial alternating current stimulation (tACS), has become an essential tool to understand the causal role of neuronal oscillations in cognition and behavior. However, conventional sinusoidal tACS limits the ability to record neuronal activity during stimulation and lacks spatial focality. One particularly promising new tACS stimulation paradigm uses amplitude-modulated (AM) high-frequency waveforms (AM-tACS) with a slow signal envelope that may overcome the limitations. Moreover. AM-tACS using high-frequency carrier signals is more tolerable than conventional tACS, e.g. in terms of skin irritation and occurrence of phosphenes, when applied at the same current intensities (e.g. 1-2 mA). Yet, the fundamental mechanism of neuronal target-engagement by AM-tACS waveforms has remained unknown. We used a computational model of cortex to investigate how AM-tACS modulates endogenous oscillations and compared the target engagement mechanism to the case of conventional (unmodulated) low-frequency tACS. Analysis of stimulation amplitude and strength indicated that cortical oscillations were phase-locked to the envelope of the AM stimulation signal, which thus exhibits the same target engagement mechanism as conventional (unmodulated) low frequency tACS. However, in the computational model substantially higher current intensities were needed for AM-tACS than for low-frequency (unmodulated) tACS waveforms to achieve pronounced phase synchronization. Our analysis of the carrier frequency suggests that there might be a trade-off between the use of high-frequency carriers and the stimulation amplitude required for successful entrainment. Together, our computational simulations support the use of slow-envelope high frequency carrier AM waveforms as a tool for noninvasive modulation of brain oscillations. More empirical data will be needed to identify the optimal stimulation parameters and to evaluate tolerability and safety of both, AM- and conventional tACS.
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DOI：
10.1085/jgp.27.1.37
发表时间：
1943-09-20
期刊：
The Journal of general physiology
影响因子：
--
作者：
Goldman DE
通讯作者：
Goldman DE
影响因子：
5.3
作者：
Chander BS;Witkowski M;Braun C;Robinson SE;Born J;Cohen LG;Birbaumer N;Soekadar SR
通讯作者：
Soekadar SR
影响因子：
5.7
作者：
Doelling, Keith B.;Arnal, Luc H.;Ghitza, Oded;Poeppel, David
通讯作者：
Poeppel, David
影响因子：
5.3
作者：
Ali, Mohsin M.;Sellers, Kristin K.;Frohlich, Flavio
通讯作者：
Frohlich, Flavio
影响因子：
5.3
作者：
Herrmann, Christoph S.;Murray, Micah M.;Lefebvre, Jeremie
通讯作者：
Lefebvre, Jeremie