Adjunctive chemotherapeutic suppression of mutans streptococci in the setting of severe early childhood caries: an exploratory study.
Adjunctive chemotherapeutic suppression of mutans streptococci in the setting of severe early childhood caries: an exploratory study.
复制标题
DOI：
10.1111/j.1752-7325.2009.00118.x
复制
发表时间：
2009
影响因子：
2.3
通讯作者：
Billings R
中科院分区：
文献类型：
--
作者：
Berkowitz RJ;Koo H;McDermott MP;Whelehan MT;Ragusa P;Kopycka-Kedzierawski DT;Karp JM;Billings R
这项调查性研究评估了10%聚维酮碘（PI）联合消除活动性龋损对重度幼儿龋（S-ECC）儿童唾液变形链球菌（MS）种群的抑制作用。77名儿童（38名女性，39名男性）在一个疗程中接受了S-ECC治疗;在牙科手术完成后，将0.2 ml PI溶液应用于牙列并立即擦拭。基线时受试者的年龄为2 - 5岁（平均= 3.78岁）。在基线、牙科手术后30天、60天和90天获得完整的非刺激唾液样本。将样品置于冰上并在2小时内处理。每个样品中的MS水平表示为每ml唾液的菌落形成单位（CFU）。大约50%的受试者在基线后的每个时间点唾液CFU/ml减少> 95%。MS水平降低> 50%的受试者百分比在30天为85%，60天为83%，90天为84%。中位数第25、75周唾液CFU/ml为8.40 × 105基线时（1.49 × 105，5.00 × 106）（n = 77），4.12 × 104（8.40 × 103，1.89 × 105）30天时（n = 74），4.62 × 104（7.00 × 103，1.36 × 105），90天（n = 70）时为5.09 × 104（1.16 × 104，1.00 × 105）。从基线到30天、60天和90天的变化具有统计学意义（P < 0.0001）。PI结合牙科手术在S-ECC的设置中对唾液MS水平具有显著的抑制作用至少90天。这些数据强烈表明，PI治疗可能是S-ECC牙科手术的重要辅助手段。
This investigational study assessed the suppressive effect of 10 percent povidone iodine (PI) coupled with elimination of active carious lesions on salivary mutans streptococci (MS) populations in children with severe early childhood caries (S-ECC). 77 children (38 females, 39 males) were treated for S- ECC in one session; a 0.2 ml PI solution was applied to the dentition after dental surgery was completed and immediately wiped off. The subjects aged from 2 to 5 years (mean = 3.78 years) at baseline. Whole nonstimulated saliva samples were obtained at baseline, 30 days, 60 days, and 90 days post dental surgery. Samples were placed on ice and processed within 2 hours. The MS level in each sample was expressed as colony forming units (CFUs) per ml of saliva. Approximately 50 percent of subjects had a >95 percent reduction in CFU/ml of saliva at each time point after baseline. The percentages of subjects with a >50 percent reduction in MS level were 85 percent at 30 days, 83 percent at 60 days, 84 percent at 90 days. The median (25th, 75th percentiles) CFUs/ml of saliva counts were 8.40 × 105 (1.49 × 105, 5.00 × 106) at baseline (n = 77), 4.12 × 104 (8.40 × 103, 1.89 × 105) at 30 days (n = 74), 4.62 × 104 (7.00 × 103, 1.36 × 105) at 60 days (n = 70), and 5.09 × 104 (1.16 × 104, 1.00 × 105) at 90 days (n = 70). The changes from baseline to 30 days, 60 days, and 90 days were statistically significant (P < 0.0001). PI coupled with dental surgery has a significant suppressive effect on salivary MS levels in the setting of S-ECC for at least 90 days. These data strongly suggest that treatment with PI may be an important adjunct to dental surgery for S-ECC.
登录
查看更多内容
影响因子：
4.9
作者：
Koo, H;Rosalen, PL;Bowen, WH
通讯作者：
Bowen, WH
DOI：
10.1034/j.1600-0528.2000.280106.x
发表时间：
2000-02-01
影响因子：
2.3
作者：
Fyffe, HE;Deery, C;Pitts, NB
通讯作者：
Pitts, NB
DOI：
10.1046/j.1365-263x.1999.00108.x
发表时间：
1999-06-01
影响因子：
3.8
作者：
Twetman, S;Fritzon, B;Stahl, B
通讯作者：
Stahl, B
影响因子：
7.6
作者：
CAUFIELD, PW;GIBBONS, RJ
通讯作者：
GIBBONS, RJ
影响因子：
3.1
作者：
GIBBONS, RJ;DEPAOLA, PF;SKOBE, Z
通讯作者：
SKOBE, Z