No increased mortality with early aortic aneurysm disease.
No increased mortality with early aortic aneurysm disease.
复制标题
早期主动脉瘤疾病的死亡率不会增加。
DOI：
10.1016/j.jvs.2012.04.023
复制
发表时间：
2012
影响因子：
4.3
通讯作者：
StanfordAbdominalAorticAneurysmSpecializedCenterofClinicallyOrientedResearchInvestigators
中科院分区：
文献类型：
--
作者：
Mell,Matthew;White,JulieJ;Hill,BradleyB;Hastie,Trevor;Dalman,RonaldL;StanfordAbdominalAorticAneurysmSpecializedCenterofClinicallyOrientedResearchInvestigators
除了腹主动脉瘤相关死亡的风险增加外，先前的研究已经确定腹主动脉瘤（AAA）患者的全因死亡率过高，与冠心病相关死亡率相当。然而，这些研究在很大程度上先于当前的冠心病风险因素管理时代，并且最近没有研究检查与早期AAA疾病（动脉瘤直径在3 - 5 cm之间）相关的当代死亡率。作为一个正在进行的AAA的自然史研究的一部分，我们报告的死亡风险与存在的早期diseases. METHODS参与者招募从三个不同的医疗保健系统在北方加州之间的2006年和2011年。在研究入组时收集动脉瘤直径、人口统计学信息、合并症、用药史和用于生物标志物分析的血浆。在随访时确定生存状态。适当时，采用t检验或χ 2检验分析数据。通过考克斯比例风险模型计算免于死亡率;通过对数秩检验确定个体预测因子对死亡率的相关性。参与者大多为男性（88.8%），目前不吸烟（81.6%），并服用他汀类药物（76.7%）。平均随访时间为2.1 ± 1.0年。估计1年和3年生存率分别为98.2%和90.9%。与死亡率独立相关的因素包括较大的动脉瘤尺寸（风险比，2.12; 95%置信区间，1.26-3.57，直径>4.0 cm）和糖尿病（风险比，2.24; 95%置信区间，1.12-4.47）。调整患者水平的因素后，卫生保健系统独立预测mortality. CONCLUSIONSTemporary全因死亡率为早期AAA疾病的患者低于以前报道的。需要进一步研究以确定有助于改善早期AAA疾病生存率的重要因素。
OBJECTIVEIn addition to increased risks for aneurysm-related death, previous studies have determined that all-cause mortality in abdominal aortic aneurysm (AAA) patients is excessive and equivalent to that associated with coronary heart disease. These studies largely preceded the current era of coronary heart disease risk factor management, however, and no recent study has examined contemporary mortality associated with early AAA disease (aneurysm diameter between 3 and 5 cm). As part of an ongoing natural history study of AAA, we report the mortality risk associated with presence of early disease.METHODSParticipants were recruited from three distinct health care systems in Northern California between 2006 and 2011. Aneurysm diameter, demographic information, comorbidities, medication history, and plasma for biomarker analysis were collected at study entry. Survival status was determined at follow-up. Data were analyzed with t-tests or χ2tests where appropriate. Freedom from death was calculated via Cox proportional hazards modeling; the relevance of individual predictors on mortality was determined by log-rank test.RESULTSThe study enrolled 634 AAA patients; age 76.4 ± 8.0 years, aortic diameter 3.86 ± 0.7 cm. Participants were mostly male (88.8%), not current smokers (81.6%), and taking statins (76.7%). Mean follow-up was 2.1 ± 1.0 years. Estimated 1- and 3-year survival was 98.2% and 90.9%, respectively. Factors independently associated with mortality included larger aneurysm size (hazard ratio, 2.12; 95% confidence interval, 1.26-3.57 for diameter >4.0 cm) and diabetes (hazard ratio, 2.24; 95% confidence interval, 1.12-4.47). After adjusting for patient-level factors, health care system independently predicted mortality.CONCLUSIONSContemporary all-cause mortality for patients with early AAA disease is lower than that previously reported. Further research is warranted to determine important factors that contribute to improved survival in early AAA disease.
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影响因子：
4.3
作者：
Sweeting, Michael J.;Thompson, Simon G.;Powell, Janet T.
通讯作者：
Powell, Janet T.
影响因子：
37.8
作者：
Smith, Sidney C., Jr.;Allen, Jerilyn;Taubert, Kathryn A.
通讯作者：
Taubert, Kathryn A.
腹主动脉瘤或直径相对较大的非动脉瘤主动脉会增加总死亡率和心血管死亡率：特罗姆瑟研究。
影响因子：
7.7
作者：
S. Forsdahl;S. Solberg;Kulbir Singh;B. Jacobsen
通讯作者：
B. Jacobsen
影响因子：
4.8
作者：
Ferguson, Craig D.;Clancy, Paula;Bourke, Bernard;Walker, Philip J.;Dear, Anthony;Buckenham, Tim;Norman, Paul;Golledge, Jonathan
通讯作者：
Golledge, Jonathan
卢瑟福的血管外科，第七版
DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
B. Galland
通讯作者：
B. Galland