Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review.
Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review.
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暴露于必需和非必需微量元素与先天性心脏病风险：一项叙述性综述。
DOI：
10.3389/fnut.2023.1121826
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发表时间：
2023
影响因子：
5
通讯作者：
Zhang, Nannan
中科院分区：
文献类型：
--
作者：
Liang, Yipu;Pan, Zijian;Zhu, Mingzheng;Gao, Ruonan;Wang, Yijue;Cheng, Yijuan;Zhang, Nannan
先天性心脏缺陷（CHD）是涉及心脏和大血管总体结构的先天性异常。环境因素、遗传因素及其相互作用可能导致先心病的发病。一般来说，微量元素可分为必需微量元素和非必需微量元素。铜（Cu）、锌（Zn）、铁（Fe）、硒（Se）和锰（Mn）等必需微量元素在代谢功能、氧化应激调节和胚胎发育等人体生物功能中发挥着重要作用。镉 (Cd)、砷 (As)、铅 (Pb)、镍 (Ni)、钡 (Ba)、铬 (Cr) 和汞 (Hg) 等非必需微量元素即使在低浓度下也对健康有害。最近的研究揭示了这些微量元素可能参与先心病的发病机制。在这篇综述中，我们总结了当前探讨必需和非必需微量元素暴露以及冠心病风险的研究，以期为冠心病的发病机制和预防提供进一步的见解。
Congenital heart defects (CHDs) are congenital abnormalities involving the gross structures of the heart and large blood vessels. Environmental factors, genetic factors and their interactions may contribute to the pathogenesis of CHDs. Generally, trace elements can be classified into essential trace elements and non-essential trace elements. Essential trace elements such as copper (Cu), zinc (Zn), iron (Fe), selenium (Se), and manganese (Mn) play important roles in human biological functions such as metabolic function, oxidative stress regulation, and embryonic development. Non-essential trace elements such as cadmium (Cd), arsenic (As), lead (Pb), nickle (Ni), barium (Ba), chromium (Cr) and mercury (Hg) are harmful to health even at low concentrations. Recent studies have revealed the potential involvement of these trace elements in the pathogenesis of CHDs. In this review, we summarized current studies exploring exposure to essential and non-essential trace elements and risks of CHDs, in order to provide further insights for the pathogenesis and prevention of CHDs.
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影响因子：
4.1
作者：
Cao, Liang;Huang, Wei;Dou, Shuozeng
通讯作者：
Dou, Shuozeng
影响因子：
4
作者：
Dennerlein, Sven;Rehling, Peter
通讯作者：
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影响因子：
4.2
作者：
Andersen, HS;Gambling, L;McArdle, HJ
通讯作者：
McArdle, HJ
影响因子：
7.4
作者：
Beckers-Trapp, ME;Lanoue, L;Uriu-Adams, JY
通讯作者：
Uriu-Adams, JY
影响因子：
3.8
作者：
Allison, Patrick;Huang, Tianfang;Broka, Derrick;Parker, Patti;Barnett, Joey V.;Camenisch, Todd D.
通讯作者：
Camenisch, Todd D.