Gammaherpesvirus gene expression and DNA synthesis are facilitated by viral protein kinase and histone variant H2AX.
Gammaherpesvirus gene expression and DNA synthesis are facilitated by viral protein kinase and histone variant H2AX.
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病毒蛋白激酶和组蛋白变体 H2AX 促进了 γ 疱疹病毒基因表达和 DNA 合成。
DOI：
10.1016/j.virol.2011.08.019
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Tarakanova,VeraL
中科院分区：
文献类型：
--
作者：
Mounce,BryanC;Tsan,FeiChin;Droit,Lindsay;Kohler,Sarah;Reitsma,JustinM;Cirillo,LisaA;Tarakanova,VeraL
Gammaherpesvirus protein kinases are an attractive therapeutic target as they support lytic replication and latency. Via an unknown mechanism these kinases enhance expression of select viral genes and DNA synthesis. Importantly, the kinase phenotypes have not been examined in primary cell types. Mouse gammaherpesvirus-68 (MHV68) protein kinase orf36 activates the DNA damage response (DDR) and facilitates lytic replication in primary macrophages. Significantly, H2AX, a DDR component and putative orf36 substrate, enhances MHV68 replication. Here we report that orf36 facilitated expression of RTA, an immediate early MHV68 gene, and DNA synthesis during de novo infection of primary macrophages. H2AX expression supported efficient RTA transcription and phosphorylated H2AX associated with RTA promoter. Furthermore, viral DNA synthesis was attenuated in H2AX-deficient macrophages, suggesting that the DDR system was exploited throughout the replication cycle. The interactions between a cancer-associated gammaherpesvirus and host tumor suppressor system have important implications for the pathogenesis of gammaherpesvirus infection.
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影响因子：
16
作者：
Savic, Velibor;Yin, Bu;Maas, Nancy L.;Bredemeyer, Andrea L.;Carpenter, Andrea C.;Helmink, Beth A.;Yang-lott, Katherine S.;Sleckman, Barry P.;Bassing, Craig H.
通讯作者：
Bassing, Craig H.
Kruppel相关的盒子结构域相关蛋白-1作为Kaposi肉瘤相关的疱疹病毒的潜伏期调节剂及其通过病毒蛋白激酶的调节。
影响因子：
11.2
作者：
Chang PC;Fitzgerald LD;Van Geelen A;Izumiya Y;Ellison TJ;Wang DH;Ann DK;Luciw PA;Kung HJ
通讯作者：
Kung HJ
影响因子：
5.4
作者：
Liu, SF;Pavlova, IV;Speck, SH
通讯作者：
Speck, SH
影响因子：
30.3
作者：
Tarakanova, Vera L.;Leung-Pinecla, Van;Virgin, Herbert W., IV
通讯作者：
Virgin, Herbert W., IV
保守的伽马疱疹病毒激酶和组蛋白变体 H2AX 促进伽马疱疹病毒在体内的潜伏期。
影响因子：
3.7
作者：
V. Tarakanova;E. Stanitsa;Steven M. Leonardo;T. Bigley;S. Gauld
通讯作者：
S. Gauld