Multiple Roles for Hepatitis B and C Viruses and the Host in the Development of Hepatocellular Carcinoma.
Multiple Roles for Hepatitis B and C Viruses and the Host in the Development of Hepatocellular Carcinoma.
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DOI：
10.1002/hep.31481
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Chang KM
中科院分区：
文献类型：
--
作者：
Wangensteen KJ;Chang KM
Chronic hepatitis B and C viral infections are major risk factors for hepatocellular carcinoma (HCC) in the United States and worldwide. Direct and indirect mechanisms of viral infection lead to the development of HCC. Chronic viral infection leads to inflammation and liver damage, culminating in cirrhosis, the penultimate step in the progression toward HCC. Host, viral, and environmental factors likely interact to promote oncogenesis. Clinical considerations include recommendations for screening for HCC in persons at risk, treatment with antivirals, and an emerging role for immunotherapy in HCC. We pose unanswered questions regarding HCC susceptibility and pathogenesis in the setting of chronic hepatitis B and C.
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影响因子：
120.7
作者：
Chen, CJ;Yang, HI;Iloeje, UH
通讯作者：
Iloeje, UH
影响因子：
7.6
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Block TM;Alter H;Brown N;Brownstein A;Brosgart C;Chang KM;Chen PJ;Cohen C;El-Serag H;Feld J;Gish R;Glenn J;Greten TF;Guo JT;Hoshida Y;Kowdley KV;Li W;Lok AS;McMahon B;Mehta A;Perrillo R;Rice CM;Rinaudo J;Schinazi RF;Shetty K
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Shetty K
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64.5
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Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu;Cancer Genome Atlas Research Network
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Cancer Genome Atlas Research Network
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29.4
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通讯作者：
Wong, Nathalie
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64.5
作者：
CHISARI, FV;KLOPCHIN, K;PALMITER, RD
通讯作者：
PALMITER, RD