Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study
Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study
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药物诱导过度换气后的急性呼吸衰竭：实验动物研究
DOI：
10.1007/bf00255628
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发表时间：
2004
影响因子：
38.9
通讯作者：
Buckhold Dk
中科院分区：
文献类型：
--
作者：
D. Mascheroni;T. Kolobow;R. Fumagalli;M. Moretti;V. Chen;Buckhold Dk
在 16 只自主呼吸的成年羊身上研究了将水杨酸钠注入小脑延髓池后过度换气对肺部的影响。我们发现，过度通气 3.5 至 13 小时后，PaO2 下降，呼吸系统静态顺应性下降，胸部 X 线片异常，肺部严重异常。对照组 15 只羊（10 只羊同样注射水杨酸钠，但随后镇静、麻痹并使用机械呼吸机以正常潮气量和呼吸频率通气，5 只羊单独输注盐水并自主呼吸）未显示肺或动脉血气异常。我们得出的结论是，在本实验条件下长时间过度换气会引发导致急性肺损伤的事件。
The pulmonary effects of hyperventilation following infusion of sodium salicylate into the cisterna magna was studied in 16 spontaneously breathing adult sheep. We found a fall in PaO2, a decrease in the static compliance of the respiratory system, abnormal chest roentgenographic films, and grossly abnormal lungs following 3.5 to 13 h of hyperventilation. A control group of 15 sheep (10 sheep similarly injected with sodium salicylate, but then sedated and paralyzed and ventilated at normal tidal volume and respiratory rate on a mechanical ventilator, and 5 sheep infused with saline alone and breathing spontaneously) showed no pulmonary or arterial blood gas abnormalities. We conclude that prolonged hyperventilation under the conditions of this experiment precipitated events that resulted in acute lung injury.
增加通气量对未麻醉绵羊肺淋巴流量的影响。
DOI：
10.1152/jappl.1986.60.6.2063
发表时间：
1986
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Albelda,SM;Hansen-Flaschen,JH;Lanken,PN;Fishman,AP
通讯作者：
Fishman,AP