Intracellular Characterization of Song-Specific Neurons in the Zebra Finch Auditory Forebrain
Intracellular Characterization of Song-Specific Neurons in the Zebra Finch Auditory Forebrain
复制标题
斑马雀听觉前脑中歌曲特异性神经元的细胞内特征
作者：
M. Lewicki
前脑核HVc（hyperstriatum ventrale pars caudale）中的听觉神经元对鸟自己的歌曲的时间结构高度敏感。这些“歌曲特异性”神经元对向前的歌曲反应强烈，对音节顺序颠倒的歌曲反应较弱，对颠倒的歌曲反应很小或根本没有反应。为了研究这些反应的细胞机制，从成年HVc神经元进行体内细胞内记录。歌曲特异性细胞可以分为那些在整个自体歌曲中强烈反应的细胞（紧张性细胞）和那些在歌曲中特定点处以动作电位爆发反应的细胞（相位细胞）。相细胞超极化过程中自体的歌曲，即使这种刺激也引起了最强烈的反应。同一首歌曲中，音节顺序相反的超极化现象较少，而颠倒的歌曲中则无超极化现象。这两种类型的歌曲特异性细胞的反应包含高频率的动作电位爆发。时相细胞的爆发显示动作电位高度的衰减和每个峰后缺乏完全复极。这种类型的爆发显着相关的金额超极化之前，每一个突发的相位细胞和非听觉细胞，产生这样的突发自发。这些数据表明，歌曲特异性神经元使用持久的超极化作为一种机制，以整合听觉上下文，时间顺序选择性的一个重要组成部分。超极化也可能增加尖峰时间的精确性，这可能对促进歌曲学习和产生的神经代码很重要。
Auditory neurons in the forebrain nucleus HVc (hyperstriatum ventrale pars caudale) are highly sensitive to the temporal structure of the bird’s own song. These “song-specific” neurons respond strongly to forward song, weakly to the song with the order of the syllables reversed, and little or not at all to reversed song. To investigate the cellular mechanisms underlying these responses,in vivo intracellular recordings were made from adult HVc neurons. Song-specific cells could be divided into those that responded strongly throughout autogenous song (tonic cells) and those that responded with bursts of action potentials at specific points during the song (phasic cells). Phasic cells were hyperpolarized during autogenous song, even though this stimulus also elicited the strongest response. Less hyperpolarization was seen to the same song with the syllables in reverse order, and none was seen to reversed song. The responses of both types of song-specific cells contained high-frequency bursts of action potentials. The bursts of the phasic cells showed attenuation of the action potential height and lack of full repolarization after each spike. This type of bursting was significantly correlated with the amount of hyperpolarization before each burst in phasic cells and nonauditory cells that generated such bursts spontaneously. These data suggest that song-specific neurons use long-lasting hyperpolarization as a mechanism to integrate auditory context, an important component of temporal order selectivity. Hyperpolarization also may increase the precision of spike timing, which could be important for the neural code subserving song learning and production.
斑胸草雀 HVc 对自体鸣叫的全局同步响应。
影响因子：
2.5
作者：
Sutter,ML;Margoliash,D
通讯作者：
Margoliash,D
斑胸草雀前脑声音控制核的歌曲选择性听觉输入。
DOI：
10.1002/neu.480240407
发表时间：
1993
期刊：
Journal of neurobiology
影响因子：
--
作者：
Vicario,DS;Yohay,KH
通讯作者：
Yohay,KH
影响因子：
56.9
作者：
BOTTJER, SW;MIESNER, EA;ARNOLD, AP
通讯作者：
ARNOLD, AP