Cardiorespiratory fitness and brain atrophy in early Alzheimer disease.
Cardiorespiratory fitness and brain atrophy in early Alzheimer disease.
复制标题
DOI：
10.1212/01.wnl.0000317094.86209.cb
复制
发表时间：
2008-07-15
期刊：
影响因子：
9.9
通讯作者：
Swerdlow RH
中科院分区：
文献类型：
--
作者：
Burns JM;Cronk BB;Anderson HS;Donnelly JE;Thomas GP;Harsha A;Brooks WM;Swerdlow RH
检查心肺功能与早期阿尔茨海默病（AD）脑萎缩和认知的相关性。在正常的衰老过程中，身体健康似乎可以减轻与年龄相关的大脑功能和结构变化。这是否在AD中观察到尚不清楚。非痴呆（n=64）和早期AD受试者（n=57）进行MRI和标准临床和心理测量评估。峰值氧耗量（VO 2 peak）是心肺功能的标准指标，在分级跑台试验中进行评估。通过MRI测定标准化全脑体积（脑萎缩估计值）。皮尔森相关性和线性回归被用来评估与脑容量和认知能力有关的健康状况。AD受试者的呼吸适应性（VO 2峰值）（34.7（5.0）ml/kg/min）与非痴呆受试者（38.1（6.3）ml/kg/min，p=0.002）相比略有降低。在早期AD中，在控制年龄后，VO 2峰值与全脑体积（β =0.35，p=0.02）和白色体积（β =0.35，p=0.04）相关。控制额外的协变量性别，痴呆的严重程度，体力活动，身体虚弱并没有减弱的关系。VO 2峰值与AD早期的延迟记忆和数字符号成绩相关，但在控制年龄后不相关。在非痴呆的参与者中，健身和脑萎缩之间没有关系。非痴呆受试者的健康状况与更好的整体认知能力（r=0.30，p=0.02）以及在线索确定A和B、Stroop和延迟逻辑记忆方面的表现相关，但在控制年龄后则无关。增加心肺适应性与减少AD患者的脑萎缩相关。心肺适应性可能会缓解AD相关的脑萎缩，或者一种常见的潜在AD相关过程可能会影响脑萎缩和心肺适应性。
Examine the correlation of cardiorespiratory fitness with brain atrophy and cognition in early-stage Alzheimer’s disease (AD). In normal aging physical fitness appears to mitigate functional and structural age-related brain changes. Whether this is observed in AD is not known. Nondemented (n=64) and early-stage AD subjects (n=57) had MRI and standard clinical and psychometric evaluations. Peak oxygen consumption (VO2peak), the standard measure of cardiorespiratory fitness, was assessed during a graded treadmill test. Normalized whole brain volume, a brain atrophy estimate, was determined by MRI. Pearson’s correlation and linear regression were used to assess fitness in relation to brain volume and cognitive performance. Cardiorespiratory fitness (VO2peak) was modestly reduced in AD (34.7(5.0)ml/kg/min) vs. nondemented subjects (38.1(6.3)ml/kg/min, p=0.002). In early AD, VO2peak was associated with whole brain volume (beta=0.35, p=0.02) and white matter volume (beta=0.35, p=0.04) after controlling for age. Controlling for additional covariates of sex, dementia severity, physical activity, and physical frailty did not attenuate the relationships. VO2peak was associated with performance on delayed memory and digit symbol in early AD but not after controlling for age. In nondemented participants, there was no relationship between fitness and brain atrophy. Fitness in nondemented participants was associated with better global cognitive performance (r=0.30, p=0.02) and performance on Trailmaking A and B, Stroop, and delayed logical memory but not after controlling for age. Increased cardiorespiratory fitness is associated with reduced brain atrophy in AD. Cardiorespiratory fitness may moderate AD-related brain atrophy or a common underlying AD-related process may impact both brain atrophy and cardiorespiratory fitness.
登录
查看更多内容
影响因子：
5.3
作者：
Adlard, PA;Perreau, VM;Cotman, CW
通讯作者：
Cotman, CW
影响因子：
2.5
作者：
BRUEL, A;CHERQUI, G;DELABAR, J
通讯作者：
DELABAR, J
影响因子：
5
作者：
Fraser, GE;Singh, PN;Bennett, H
通讯作者：
Bennett, H
DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV
影响因子：
3.7
作者：
Hugenschmidt, Christina E.;Peiffer, Ann M.;Laurienti, Paul J.
通讯作者：
Laurienti, Paul J.