ALKing the flames of lung cancer immunosensitivity.
ALKing the flames of lung cancer immunosensitivity.
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DOI：
10.1002/1878-0261.13533
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发表时间：
2023-11
影响因子：
6.6
通讯作者：
Sampson, Josephina
中科院分区：
文献类型：
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作者：
Bayliss, Richard;Sarnowska, Elzbieta;Yeoh, Sharon;Sampson, Josephina
免疫检查点抑制剂（ICI）通过增强对癌细胞的免疫反应来治疗非小细胞肺癌（NSCLC）。然而，它们对某些遗传改变的癌症无效。Mota等人最近的一项研究重点是了解为什么ALK+ NSCLC癌症是免疫冷的，并使用基于疫苗的方法使它们更容易接受ICI。该研究强调了免疫原性肽呈递和肿瘤位置的细胞特异性差异是免疫应答差的因素。基于ALK肽的疫苗改善了免疫应答，当与ICI组合时，这导致ALK+ NSCLC小鼠模型的存活率显著改善。非小细胞肺癌（NSCLC）患者的某些亚组受益于免疫检查点抑制剂（ICI）。最近的一项研究强调了ALK+ NSCLC癌症免疫应答差的因素，例如免疫原性肽呈递和肿瘤部位的细胞特异性差异。基于ALK肽的疫苗联合ICI可提高ALK+ NSCLC小鼠模型的存活率。
Immune checkpoint inhibitors (ICIs) are utilised in treating non‐small cell lung cancer (NSCLC) by enhancing the immune response against cancer cells. However, they are not effective against cancers with certain genetic alterations. A recent study by Mota et al. focussed on understanding why ALK+ NSCLC cancers are immune cold and making them more receptive to ICIs using a vaccine‐based approach. The study highlighted cell‐specific differences in the presentation of immunogenic peptides and the location of tumours as factors in the poor immune response. Vaccines based on ALK peptides improved immune response, and when combined with ICIs, this led to a striking improvement in survival in a mouse model of ALK+ NSCLC. Certain subgroups of non‐small cell lung cancer (NSCLC) patients benefit from immune checkpoint inhibitors (ICIs). A recent study highlighted factors in the poor immune response of ALK+ NSCLC cancers such as cell‐specific differences in the presentation of immunogenic peptides and the tumour site. Vaccines based on ALK peptides combined with ICIs enhanced survival in a mouse model of ALK+ NSCLC.
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影响因子：
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作者：
Awad MM;Mastini C;Blasco RB;Mologni L;Voena C;Mussolin L;Mach SL;Adeni AE;Lydon CA;Sholl LM;Jänne PA;Chiarle R
通讯作者：
Chiarle R
DOI：
10.1158/1078-0432.ccr-15-3101
发表时间：
2016-09-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Gainor JF;Shaw AT;Sequist LV;Fu X;Azzoli CG;Piotrowska Z;Huynh TG;Zhao L;Fulton L;Schultz KR;Howe E;Farago AF;Sullivan RJ;Stone JR;Digumarthy S;Moran T;Hata AN;Yagi Y;Yeap BY;Engelman JA;Mino-Kenudson M
通讯作者：
Mino-Kenudson M
影响因子：
6.4
作者：
Christopoulos, P.;Kirchner, M.;Stenzinger, A.
通讯作者：
Stenzinger, A.
影响因子：
10.1
作者：
Voena C;Menotti M;Mastini C;Di Giacomo F;Longo DL;Castella B;Merlo MEB;Ambrogio C;Wang Q;Minero VG;Poggio T;Martinengo C;D'Amico L;Panizza E;Mologni L;Cavallo F;Altruda F;Butaney M;Capelletti M;Inghirami G;Jänne PA;Chiarle R
通讯作者：
Chiarle R
影响因子：
56.9
作者：
Sjostedt, Evelina;Zhong, Wen;Mulder, Jan
通讯作者：
Mulder, Jan