Temporal trends of subsequent breast cancer among women with ovarian cancer: a population-based study.
Temporal trends of subsequent breast cancer among women with ovarian cancer: a population-based study.
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DOI：
10.1007/s00404-020-05508-3
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发表时间：
2020-05
影响因子：
2.6
通讯作者：
Wright JD
中科院分区：
文献类型：
--
作者：
Matsuo K;Mandelbaum RS;Machida H;Yoshihara K;Matsuzaki S;Klar M;Muggia FM;Roman LD;Wright JD
研究同时患卵巢癌和乳腺癌的女性的趋势、特征和结果。这是一项回顾性研究，检查了1973年至2013年的监测、流行病学和最终结果项目。在卵巢癌（n = 133,149）和乳腺癌（n = 1,143,219）队列中，确定了两种诊断的女性，并检查了时间趋势、肿瘤特征和生存率。有6446名女性同时患有这两种恶性肿瘤，分别占卵巢癌队列的4.8%和乳腺癌队列的0.6%。在研究早期，患有继发性乳腺癌的卵巢癌妇女比没有继发性乳腺癌的妇女年轻（1973年为52.3比59.2），但近年来年龄增加（2013年为68.5比62.1,P < 0.001）。从1979年到2008年，乳腺癌幸存者罹患卵巢癌的比例从1.5%下降到0.2%（相对风险降低90.0%,P < 0.05）。同样，从1973年到2008年，卵巢癌幸存者中患乳腺癌的人数从7.2%下降到2.0%（相对风险降低72.4%,P < 0.05）。肿瘤特征在发生乳腺癌后的卵巢癌妇女中更可能是有利的，而在发生乳腺癌前的妇女中则是不利的（均P < 0.05）。与未患乳腺癌的妇女相比，患有继发性乳腺癌的卵巢癌妇女的病因特异性生存率更高，与乳腺癌发生时间无关（P < 0.05）。我们的研究表明，随着时间的推移，患乳腺癌和卵巢癌的妇女的人口统计数据发生了变化，卵巢癌后继发性乳腺癌的诊断减少了。
To examine trends, characteristics and outcomes of women who develop both ovarian and breast cancers. This is a retrospective study examining the Surveillance, Epidemiology, and End Results Program from 1973 to 2013. Among ovarian cancer (n = 133,149) and breast cancer (n = 1,143,219) cohorts, women with both diagnoses were identified and temporal trends, tumor characteristics and survival were examined. There were 6446 women with both malignancies, representing 4.8% of the ovarian cancer cohort and 0.6% of the breast cancer cohort. Women with ovarian cancer who had secondary breast cancer were younger than those without secondary breast cancer early in the study period (52.3 versus 59.2 in 1973) but older in more recent years (68.5 versus 62.1 in 2013, P < 0.001). The number of breast cancer survivors who developed postcedent ovarian cancer decreased from 1.5 to 0.2% from 1979 to 2008 (relative risk reduction 90.0%, P < 0.05). Similarly, the number of ovarian cancer survivors who developed postcedent breast cancer decreased from 7.2 to 2.0% from 1973 to 2008 (relative risk reduction 72.4%, P < 0.05). Tumor characteristics were more likely to be favorable in women with ovarian cancer who developed postcedent breast cancer but unfavorable in those who had antecedent breast cancer (all, P < 0.05). Women with ovarian cancer who had secondary breast cancer had superior cause-specific survival compared to those who did not develop breast cancer regardless of breast cancer timing (P < 0.05). Our study demonstrated that the demographics of women who develop breast cancer and ovarian cancer have changed over time and diagnosis of secondary breast cancer after ovarian cancer has decreased.
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影响因子：
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作者：
Mcgee, Jacob;Giannakeas, Vasily;Narod, Steven A.
通讯作者：
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