Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review.
Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review.
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DOI:
10.3389/fimmu.2023.1115794
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发表时间:
2023
影响因子:
7.3
通讯作者:
Chai, Zhengbin
中科院分区:
文献类型:
--
作者:
Zhu, Changhui;Liu, Chunyan;Chai, Zhengbin
The peptidyl arginine deiminase (PADI) family is a calcium ion-dependent group of isozymes with sequence similarity that catalyze the citrullination of proteins. Histones can serve as the target substrate of PADI family isozymes, and therefore, the PADI family is involved in NETosis and the secretion of inflammatory cytokines. Thus, the PADI family is associated with the development of inflammatory autoimmune diseases and cancer, reproductive development, and other related diseases. In this review, we systematically discuss the role of the PADI family in the pathogenesis of various diseases based on studies from the past decade to provide a reference for future research.
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