Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review.

Role of the PADI family in inflammatory autoimmune diseases and cancers: A systematic review.
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DOI:
10.3389/fimmu.2023.1115794
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发表时间:
2023
影响因子:
7.3
通讯作者:
Chai, Zhengbin
Chai, Zhengbin
中科院分区:
医学2区
文献类型:
--
作者:
Zhu, Changhui;Liu, Chunyan;Chai, Zhengbin

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肽基精氨酸脱亚氨酶(PADI)家族是一类具有序列相似性的钙离子依赖性同工酶,催化蛋白质的瓜氨酸化。组蛋白可作为PADI家族同工酶的靶底物,因此,PADI家族参与NETosis和炎性细胞因子的分泌。因此,PADI家族与炎性自身免疫性疾病和癌症、生殖发育和其他相关疾病的发展有关。本文就近十年来PADI家族在多种疾病发病机制中的作用进行综述,以期为今后的研究提供参考。
The peptidyl arginine deiminase (PADI) family is a calcium ion-dependent group of isozymes with sequence similarity that catalyze the citrullination of proteins. Histones can serve as the target substrate of PADI family isozymes, and therefore, the PADI family is involved in NETosis and the secretion of inflammatory cytokines. Thus, the PADI family is associated with the development of inflammatory autoimmune diseases and cancer, reproductive development, and other related diseases. In this review, we systematically discuss the role of the PADI family in the pathogenesis of various diseases based on studies from the past decade to provide a reference for future research.
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