Mitochondrial transplantation strategies as potential therapeutics for central nervous system trauma.
Mitochondrial transplantation strategies as potential therapeutics for central nervous system trauma.
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DOI：
10.4103/1673-5374.226382
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发表时间：
2018-03
影响因子：
6.1
通讯作者：
Rabchevsky AG
中科院分区：
文献类型：
--
作者：
Gollihue JL;Patel SP;Rabchevsky AG
线粒体是重要的细胞器，对于产生用于细胞内稳态的三磷酸腺苷以及可导致坏死和凋亡的各种机制至关重要。“线粒体医学”领域正在出现，其中损伤/疾病状态在治疗上靶向于线粒体水平，包括特异性抗氧化剂、生物能底物添加剂和膜解偶联剂。因此，新的线粒体移植策略代表了一种潜在的多因素治疗，导致三磷酸腺苷产生增加，氧化应激降低，线粒体DNA置换，生物能量学改善和组织保护。在此，我们简要描述了线粒体移植的历史和用于体外和体内递送的各种技术，与成功转移到外周和中枢神经系统组织相关的益处，沿着阻碍这种新型治疗方法进步的警告和陷阱。
Mitochondria are essential cellular organelles critical for generating adenosine triphosphate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of “mitochondrial medicine” is emerging in which injury/disease states are targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. Consequently, novel mitochondrial transplantation strategies represent a potentially multifactorial therapy leading to increased adenosine triphosphate production, decreased oxidative stress, mitochondrial DNA replacement, improved bioenergetics and tissue sparing. Herein, we describe briefly the history of mitochondrial transplantation and the various techniques used for both in vitro and in vivo delivery, the benefits associated with successful transference into both peripheral and central nervous system tissues, along with caveats and pitfalls that hinder the advancements of this novel therapeutic.
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影响因子：
7.7
作者：
Hilgemann DW;Fine M;Linder ME;Jennings BC;Lin MJ
通讯作者：
Lin MJ
影响因子：
3
作者：
Gollihue, Jenna L.;Patel, Samir P.;Rabchevsky, Alexander G.
通讯作者：
Rabchevsky, Alexander G.
影响因子：
4.4
作者：
Gollihue JL;Rabchevsky AG
通讯作者：
Rabchevsky AG
DOI：
10.1152/ajpheart.00883.2012
发表时间：
2013-04-01
影响因子：
4.8
作者：
Masuzawa, Akihiro;Black, Kendra M.;McCully, James D.
通讯作者：
McCully, James D.
影响因子：
64.8
作者：
Hayakawa K;Esposito E;Wang X;Terasaki Y;Liu Y;Xing C;Ji X;Lo EH
通讯作者：
Lo EH