Prospects for therapeutic mitochondrial transplantation.
Prospects for therapeutic mitochondrial transplantation.
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DOI：
10.1016/j.mito.2017.05.007
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发表时间：
2017-07
期刊：
影响因子：
4.4
通讯作者：
Rabchevsky AG
中科院分区：
文献类型：
--
作者：
Gollihue JL;Rabchevsky AG
线粒体功能障碍与多种疾病和病理状况有关-生命所必需的细胞器也可能是导致细胞死亡和疾病的主要因素。由于线粒体在我们的存在中如此完善，存在于除红细胞外的所有细胞类型中，并负责提供我们生存所需的大部分能量，因此功能失调的线粒体可能会引起破坏性的细胞病理学，这种病理学可能在整个生物体中广泛存在。因此，“线粒体医学”领域正在出现，其中疾病状态在治疗上以线粒体水平为目标，包括特定的抗氧化剂、生物能底物添加剂和膜解偶联剂。研究线粒体移植新技术的新的和令人信服的研究，以用外源性健康线粒体取代受损或功能障碍的线粒体，已经显示出有希望的结果，包括组织保留伴随着增加的能量产生和减少的氧化损伤。已经尝试了各种实验技术，并且每一种都被挑战以实现成功的移植。本综述的目的是介绍线粒体移植的历史、用于体外和体内递送的不同技术，以及沿着沿着发现的注意事项和陷阱。这些开创性研究的结果是有希望的，一旦克服技术障碍，可能成为下一个“线粒体医学”的大浪潮。
Mitochondrial dysfunction has been implicated in a multitude of diseases and pathological conditions- the organelles that are essential for life can also be major players in contributing to cell death and disease. Because mitochondria are so well established in our existence, being present in all cell types except for red blood cells and having the responsibility of providing most of our energy needs for survival, then dysfunctional mitochondria can elicit devastating cellular pathologies that can be widespread across the entire organism. As such, the field of “mitochondrial medicine” is emerging in which disease states are being targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. New and compelling research investigating novel techniques for mitochondrial transplantation to replace damaged or dysfunctional mitochondria with exogenous healthy mitochondria has shown promising results, including tissue sparing accompanied by increased energy production and decreased oxidative damage. Various experimental techniques have been attempted and each has been challenged to accomplish successful transplantation. The purpose of this review is to present the history of mitochondrial transplantation, the different techniques used for both in vitro and in vivo delivery, along with caveats and pitfalls that have been discovered along the way. Results from such pioneering studies are promising and could be the next big wave of “mitochondrial medicine” once technical hurdles are overcome.
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DOI：
10.1073/pnas.92.16.7162
发表时间：
1995-08-01
影响因子：
11.1
作者：
BONFOCO, E;KRAINC, D;LIPTON, SA
通讯作者：
LIPTON, SA
影响因子：
16.2
作者：
ANKARCRONA, M;DYPBUKT, JM;NICOTERA, P
通讯作者：
NICOTERA, P
影响因子：
3.9
作者：
CHIH, JJ;KALF, GF
通讯作者：
KALF, GF
影响因子：
168.9
作者：
Cohen, J;Scott, R;Willadsen, S
通讯作者：
Willadsen, S
影响因子：
6.7
作者：
CHEESEMAN, KH;SLATER, TF
通讯作者：
SLATER, TF