Age-related GABAA receptor changes in rat auditory cortex.
Age-related GABAA receptor changes in rat auditory cortex.
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DOI：
10.1016/j.neurobiolaging.2012.11.009
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发表时间：
2013-05
影响因子：
4.2
通讯作者：
Ling LL
中科院分区：
文献类型：
--
作者：
Caspary DM;Hughes LF;Ling LL
听觉皮层（AI）显示出与年龄相关的GABA突触前标记物减少和AI神经元反应特性退化。先前的研究发现，与年龄相关的自发和驱动活动增加，光谱和方向敏感性降低，以及新奇感检测受损。本研究探讨表达GABAA受体（GABAAR）亚单位的信息，蛋白质和定量GABAAR结合在年轻，中年和老年大鼠AI，与相邻的顶叶皮质比较。在中年和老年大鼠中观察到跨AI层的GABAAR α1亚基信息的显著丢失，而α1亚基蛋白水平在II和III层中下降。在某些AI层中观察到GABAAR α3亚基信息和蛋白水平的增加。GABAAR亚基，包括β1、β2、γ1、γ2s和γ2L，主要但不限于在信使和蛋白水平上显示出与年龄相关的下降。GABA调节[3H]TBOB在氯离子通道中结合的能力表现出与年龄相关的峰值结合减少和脱敏动力学的变化。总的来说，GABAAR亚基组成的年龄相关变化将改变抑制性突触传递的幅度和时间特性，并可能支持在老年人中观察到的与年龄相关的功能变化。
Auditory cortex (AI) shows age-related decreases in pre-synaptic markers for GABA and degraded AI neuronal response properties. Prior studies find age-related increases in spontaneous and driven activity, decreased spectral and directional sensitivity, and impaired novelty detection. The present study examined expression of GABAA receptor (GABAAR) subunit message, protein and quantitative GABAAR binding in young, middle-aged, and aged rat AI, with comparisons to adjoining parietal cortex. Significant loss of GABAAR α1 subunit message across AI layers was observed in middle-aged and aged rats while α1 subunit protein levels declined in layers II and III. Age-related increases in GABAAR α3 subunit message and protein levels were observed in certain AI layers. GABAAR subunits, including β1, β2, γ1, γ2s, and γ2L, primarily, but not exclusively, showed age-related declines at the message and protein levels. The ability of GABA to modulate [3H]TBOB binding in the chloride channel showed age-related decreases in peak binding and changes in desensitization kinetics. Collectively, age-related changes in GABAAR subunit composition would alter the magnitude and temporal properties of inhibitory synaptic transmission and could underpin observed age-related functional changes seen in the elderly.
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DOI：
10.1044/jshr.3703.662
发表时间：
1994-06-01
期刊：
JOURNAL OF SPEECH AND HEARING RESEARCH
影响因子：
--
作者：
FITZGIBBONS, PJ;GORDONSALANT, S
通讯作者：
GORDONSALANT, S
影响因子：
7.3
作者：
IM, WB;PREGENZER, JF;THOMSEN, DR
通讯作者：
THOMSEN, DR
DOI：
10.1523/jneurosci.2176-12.2012
发表时间：
2012-10-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Anderson S;Parbery-Clark A;White-Schwoch T;Kraus N
通讯作者：
Kraus N
影响因子：
2.8
作者：
GAMES, KD;WINER, JA
通讯作者：
WINER, JA
DOI：
10.1073/pnas.1007885107
发表时间：
2010-08-03
影响因子：
11.1
作者：
de Villers-Sidani, Etienne;Alzghoul, Loai;Merzenich, Michael M.
通讯作者：
Merzenich, Michael M.