MicroRNAs in shaping the resolution phase of inflammation.
MicroRNAs in shaping the resolution phase of inflammation.
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DOI：
10.1016/j.semcdb.2021.03.019
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发表时间：
2022-04
影响因子：
7.3
通讯作者：
Naqvi AR
中科院分区：
文献类型：
--
作者：
Naqvi RA;Gupta M;George A;Naqvi AR
炎症是一种通过关键因素精心安排的宿主防御机制——由细胞和分子事件介导的急性炎症反应，导致防御性免疫亚群的激活——以隔离有害损伤、病原体和受感染细胞。这些强大的炎症事件如果不受控制，可能会通过扰乱内稳态平衡向免疫失调方向发展而导致组织损伤。一种并行的宿主机制发挥作用以控制炎症通路并促进组织再生。因此，炎症的消退是对促炎通路的一种有效暂停，以避免宿主内部的组织损伤，并导致组织内稳态的重新建立。消退通路的失调会对组织功能产生有害影响，并导致疾病状态。多项报告表明，在各种促炎和抗炎事件中，微小RNA（miRNA）的表达具有特殊的动态变化。miRNA在免疫反应调节中的作用已得到充分确立。然而，对于在感染或伤口愈合模型中事件消退阶段的miRNA调节的理解仍然有限，这一阶段有时被误解为抗炎信号传导。由于miRNA在促炎和抗炎通路中的决定性作用，在本综述中，我们对miRNA在炎症消退中的假定作用提供了一个广泛的视角，并探讨了它们在治疗中的潜在作用。
Inflammation is a host defense mechanism orchestrated through imperative factors - acute inflammatory responses mediated by cellular and molecular events leading to activation of defensive immune subsets - to marginalize detrimental injury, pathogenic agents and infected cells. These potent inflammatory events, if uncontrolled, may cause tissue damage by perturbing homeostasis equilibrium towards immune dysregulation. A parallel host mechanism operates to contain inflammatory pathways and facilitate tissue regeneration. Thus, resolution of inflammation is an effective moratorium on the pro-inflammatory pathway to avoid the tissue damage inside the host and leads to reestablishment of tissue homeostasis. Dysregulation of the resolution pathway can have a detrimental impact on tissue functionality and contribute to the diseased state. Multiple reports have suggested peculiar dynamics of miRNA expression during various pro- and anti-inflammatory events. The roles of miRNAs in the regulation of immune responses are well-established. However, understanding of miRNA regulation of the resolution phase of events in infection or wound healing models, which is sometimes misconstrued as anti-inflammatory signaling, remains limited. Due to the deterministic role of miRNAs in pro-inflammatory and anti-inflammatory pathways, in this review we have provided a broad perspective on the putative role of miRNAs in the resolution of inflammation and explored their imminent role in therapeutics.
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