Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases.
Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases.
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DOI：
10.1007/s00401-020-02233-8
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发表时间：
2021-01
影响因子：
12.7
通讯作者：
Murayama S
中科院分区：
文献类型：
--
作者：
Tanei ZI;Saito Y;Ito S;Matsubara T;Motoda A;Yamazaki M;Sakashita Y;Kawakami I;Ikemura M;Tanaka S;Sengoku R;Arai T;Murayama S
路易体病（Lewy body disease，LBD）是一系列进行性神经退行性疾病，其特征在于路易体和神经突在中枢和外周神经系统（CNS，PNS）中广泛分布。临床诊断包括帕金森氏病（PD），路易体痴呆症，或纯粹的自主神经功能衰竭。所有类型的LBD都伴有非运动症状（NMS），包括胃肠功能障碍，如便秘。它与肠神经系统（ENS）的路易体相关α-突触核蛋白病（Lewy病理学）的关系引起了人们的关注，因为它可以先于运动症状。为了阐明ENS Lewy病理学在疾病进展中的作用，我们使用日本脑老化研究库进行了一项临床病理学研究。研究入组了518例病例。通过尸检结果检查CNS和PNS的Lewy病理学，包括作为ENS代表的下食管。结果显示，三分之一的老年人（178例，34%）表现为Lewy病理，其中78例（43.8%）表现为食管病理。在食管壁中，奥尔巴赫丛（41.6%）最易发生病变，其次是外膜（33.1%）和迈斯纳丛（14.6%）。食管Lewy病理与自主神经功能衰竭如便秘显著相关（p < 0.0001），在PNS区域中，与LBD进展相关性最大（r = 0.95，p < 0.05）。这些发现表明，食管Lewy病理学的传播是LBD的预测因素。本文的在线版本（10.1007/s 00401 -020-02233-8）包含补充材料，可供授权用户使用。
Lewy body disease (LBD) is a spectrum of progressive neurodegenerative disorders characterized by the wide distribution of Lewy bodies and neurites in the central and peripheral nervous system (CNS, PNS). Clinical diagnoses include Parkinson’s disease (PD), dementia with Lewy bodies, or pure autonomic failure. All types of LBD are accompanied by non-motor symptoms (NMSs) including gastrointestinal dysfunctions such as constipation. Its relationship to Lewy body-related α-synucleinopathy (Lewy pathology) of the enteric nervous system (ENS) is attracting attention because it can precede the motor symptoms. To clarify the role of ENS Lewy pathology in disease progression, we performed a clinicopathological study using the Brain Bank for Aging Research in Japan. Five-hundred and eighteen cases were enrolled in the study. Lewy pathology of the CNS and PNS, including the lower esophagus as a representative of the ENS, was examined via autopsy findings. Results showed that one-third of older people (178 cases, 34%) exhibited Lewy pathology, of which 78 cases (43.8%) exhibited the pathology in the esophagus. In the esophageal wall, Auerbach’s plexus (41.6%) was most susceptible to the pathology, followed by the adventitia (33.1%) and Meissner’s plexus (14.6%). Lewy pathology of the esophagus was significantly associated with autonomic failures such as constipation (p < 0.0001) and among PNS regions, correlated the most with LBD progression (r = 0.95, p < 0.05). These findings suggest that the propagation of esophageal Lewy pathology is a predictive factor of LBD. The online version of this article (10.1007/s00401-020-02233-8) contains supplementary material, which is available to authorized users.
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影响因子：
12.7
作者：
Doppler K;Ebert S;Uçeyler N;Trenkwalder C;Ebentheuer J;Volkmann J;Sommer C
通讯作者：
Sommer C
影响因子：
4.4
作者：
Del Tredici, Kelly;Duda, John E.
通讯作者：
Duda, John E.
DOI：
10.1093/jnen/61.5.413
发表时间：
2002-05-01
影响因子：
3.2
作者：
Del Tredici, K;Rüb, U;Braak, H
通讯作者：
Braak, H
影响因子：
9.9
作者：
Chahine LM;Beach TG;Brumm MC;Adler CH;Coffey CS;Mosovsky S;Caspell-Garcia C;Serrano GE;Munoz DG;White CL 3rd;Crary JF;Jennings D;Taylor P;Foroud T;Arnedo V;Kopil CM;Riley L;Dave KD;Mollenhauer B;Systemic Synuclein Sampling Study
通讯作者：
Systemic Synuclein Sampling Study
影响因子：
21.3
作者：
Fujiwara, H;Hasegawa, M;Iwatsubo, T
通讯作者：
Iwatsubo, T