Transperineal ultrasound is a good alternative for intra-fraction motion monitoring for prostate stereotactic body radiotherapy.
Transperineal ultrasound is a good alternative for intra-fraction motion monitoring for prostate stereotactic body radiotherapy.
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DOI：
10.1002/acm2.14021
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发表时间：
2023-10
影响因子：
2.1
通讯作者：
Xia, Ping
中科院分区：
文献类型：
--
作者：
Guo, Bingqi;Stephans, Kevin;Godley, Andrew;Kolar, Matt;Magnelli, Anthony;Tendulkar, Rahul;Mian, Omar;Majkszak, David;Xia, Ping
报告我们在一项前瞻性研究中的经验，该研究实施经会阴超声系统来监测前列腺立体定向放射治疗 (SBRT) 中的前列腺分次内运动。这项 IRB 批准的前瞻性研究纳入了 2016 年 4 月至 2019 年 11 月期间在我们机构接受治疗的 23 名前列腺 SBRT 患者。低剂量计划目标体积 (LD-PTV) 的处方剂量为 36.25 Gy，高剂量 PTV (HD-PTV) 的处方剂量为 40 Gy，分为 5 次，计划边界为 3 毫米。经会阴超声系统已成功应用于 115 个部位中的 110 个部位。对于分次内前列腺运动，导出超声测量的实时前列腺位移进行分析。计算所有患者的每个部分的前列腺运动超过 2 毫米阈值的时间百分比。所有统计比较均采用 T 检验。超声图像质量足以描绘前列腺和前列腺运动跟踪。超声引导前列腺 SBRT 下每个部分的准备时间为 15.0 ± 4.9 分钟，每个部分的总治疗时间为 31.8 ± 10.5 分钟。超声波探头的存在不会影响目标或关键结构的轮廓。对于分次内运动，23 名患者中的 11 名患者在 110 次分次中有 23 次前列腺运动超过 2 毫米耐受性。对于所有分次，每次分次期间前列腺向任意方向移动超过 2 毫米的平均时间百分比为 7%，范围从分次的 0% 到 62%。超声引导的前列腺 SBRT 是分次内运动监测的良好选择，其效率在临床上可接受。
To report our experience in a prospective study of implementing a transperineal ultrasound system to monitor intra‐fractional prostate motion for prostate stereotactic body radiotherapy (SBRT). This IRB‐approved prospective study included 23 prostate SBRT patients treated between 04/2016 and 11/2019 at our institution. The prescription doses were 36.25 Gy to the Low‐Dose planning target volume (LD‐PTV) and 40 Gy to the High‐Dose PTV (HD‐PTV) in five fractions with 3 mm planning margins. The transperineal ultrasound system was successfully used in 110 of the 115 fractions. For intra‐fraction prostate motion, the real‐time prostate displacements measured by ultrasound were exported for analysis. The percentage of time prostate movement exceeded a 2 mm threshold was calculated for each fraction of all patients. T‐test was used for all statistical comparisons. Ultrasound image quality was adequate for prostate delineation and prostate motion tracking. The setup time for each fraction under ultrasound‐guided prostate SBRT was 15.0 ± 4.9 min and the total treatment time per fraction was 31.8 ± 10.5 min. The presence of an ultrasound probe did not compromise the contouring of targets or critical structures. For intra‐fraction motion, prostate movement exceeded 2 mm tolerance in 23 of 110 fractions for 11 of 23 patients. For all fractions, the mean percentage of time when the prostate moved more than 2 mm in any direction during each fraction was 7%, ranging from 0% to 62% of a fraction. Ultrasound‐guided prostate SBRT is a good option for intra‐fraction motion monitoring with clinically acceptable efficiency.
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DOI：
10.1016/j.ijrobp.2006.10.026
发表时间：
2007-03-15
影响因子：
7
作者：
Kupelian, Patrick;Willoughby, Twyla;Levine, Lisa
通讯作者：
Levine, Lisa
DOI：
10.1016/j.ijrobp.2012.05.044
发表时间：
2013-03-01
影响因子：
7
作者：
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影响因子：
5.7
作者：
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通讯作者：
Cheng, Jason Chia-Hsien
影响因子：
3.5
作者：
van Herk, M
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影响因子：
3.3
作者：
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Schwartz，David