Antihypertensive Effect of All-cis-5,8,11,14,17-Icosapentaenoate of Aged Rats Is Associated with an Increase in the Release of ATP from the Caudal Artery
Antihypertensive Effect of All-cis-5,8,11,14,17-Icosapentaenoate of Aged Rats Is Associated with an Increase in the Release of ATP from the Caudal Artery
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全顺式 5,8,11,14,17-二十碳五烯酸对老年大鼠的抗高血压作用与尾动脉 ATP 释放的增加有关
DOI：
10.1159/000025565
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发表时间：
1998
影响因子：
1.7
通讯作者：
S. Masumura
中科院分区：
文献类型：
--
作者：
M. Hashimoto;K. Shinozuka;H. Shahdat;Y. Kwon;Y. Tanabe;M. Kunitomo;S. Masumura
鱼油已被证明可以降低高血压患者的血压。全顺式-5，8，11，14，17-二十碳五烯酸酯（EPA）是ω-3多不饱和脂肪酸之一，是鱼油中对心血管系统具有有益作用的主要活性成分之一。然而，关于EPA单独对血压的抗高血压作用知之甚少。在本研究中，我们已经确定了自发和去甲肾上腺素诱发的释放ATP，ADP，AMP，和腺苷从老年（100周龄）Wistar大鼠的尾动脉喂养标准饮食或高胆固醇饮食，EPA治疗。饮食EPA管理增加血浆和尾动脉EPA浓度和抑制血压随着年龄的增长，在老年大鼠和无高胆固醇血症。此外，与两组对照大鼠相比，去甲肾上腺素（1 µmol/l）引起EPA给药老年大鼠尾动脉中嘌呤释放量显著增加。回归分析显示动脉释放的嘌呤总量与血压之间存在显着关系。这些结果表明，EPA对老年大鼠的管理增加了ATP从血管内皮细胞的释放，导致抑制随着年龄的增长所看到的血压上升。
Fish oils have been shown to lower blood pressure in hypertensive subjects. All-cis-5,8,11,14,17-icosapentaenoate (EPA), one of the ω–3 polyunsaturated fatty acids, is known to be one of the major active components in fish oil that has beneficial effects on the cardiovascular system. However, little is known about the antihypertensive effect of EPA alone on blood pressure. In the present study, we have determined the spontaneous and noradrenaline-evoked release of ATP, ADP, AMP, and adenosine from caudal arteries of aged (100 weeks old) Wistar rats which were fed a standard diet or a high cholesterol diet, treated with EPA. Dietary EPA administration increased plasma and caudal arterial EPA concentrations and repressed increases in blood pressure with advancing age in both aged rats with and without hypercholesterolemia. In addition, noradrenaline (1 µmol/l) evoked a significantly greater release of purines from the caudal arteries of EPA-administered aged rats compared to both sets of control rats. Regression analysis revealed a significant relationship between the total amount of purines released from the artery and blood pressure. These results suggest that administration of EPA to aged rats increases the release of ATP from the vascular endothelial cells, leading to repression of the blood pressure rise seen with advancing age.
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影响因子：
21.1
作者：
H. Dalziel;David P. Westfall
通讯作者：
H. Dalziel;David P. Westfall
正常血压和高血压大鼠尾动脉之间去甲肾上腺素释放的嘌呤受体调节差异。
DOI：
--
发表时间：
1995
期刊：
The Journal of pharmacology and experimental therapeutics.
影响因子：
--
作者：
Shinozuka,K;Kunitomo,M;Hattori,K;Bjur,RA;Westfall,DP
通讯作者：
Westfall,DP
内皮依赖性反应：过去三年。
DOI：
--
发表时间：
1984
期刊：
Bibliotheca cardiologica
影响因子：
--
作者：
Furchgott,RF;Jothianandan,D;Cherry,PD
通讯作者：
Cherry,PD
心脏血管中的嘌呤能轴。
影响因子：
20.1
作者：
Yang,S;Cheek,DJ;Westfall,DP;Buxton,IL
通讯作者：
Buxton,IL
嘌呤参与甲氧胺释放去甲肾上腺素的调节。
影响因子：
5
作者：
Shinozuka,K;Sedaa,KO;Bjur,RA;Westfall,DP
通讯作者：
Westfall,DP