Frequency-dependent nanomechanical profiling for medical diagnosis.

Frequency-dependent nanomechanical profiling for medical diagnosis.
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DOI:
10.3762/bjnano.13.122
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发表时间:
2022
影响因子:
3.1
通讯作者:
Cartagena-Rivera AX
Cartagena-Rivera AX
中科院分区:
材料科学3区
文献类型:
--
作者:
Solares SD;Cartagena-Rivera AX

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20世纪80年代初发展起来的原子力显微镜(AFM)已经成为微纳尺度科学中的一种强有力的表征工具。在20世纪90年代初,它在生物学和医学研究中的相关性变得明显,尽管它在医疗保健应用中的结合仍然相对有限。在这里,我们将简要探讨技术采用率较低的原因。我们还提出了一条将频率依赖的纳米机械测量纳入综合医疗策略的前进道路,该策略将常规AFM测量与计算机分析、与医疗保健提供者的实时通信和医疗数据库联系起来。这种方法适用于癌症、狼疮、动脉硬化和关节炎等疾病,这些疾病会导致受影响组织的显著机械变化。
Atomic force microscopy (AFM), developed in the early 1980s, has become a powerful characterization tool in micro- and nanoscale science. In the early 1990s, its relevance within biology and medicine research became evident, although its incorporation into healthcare applications remains relatively limited. Here, we briefly explore the reasons for this low level of technological adoption. We also propose a path forward for the incorporation of frequency-dependent nanomechanical measurements into integrated healthcare strategies that link routine AFM measurements with computer analysis, real-time communication with healthcare providers, and medical databases. This approach would be appropriate for diseases such as cancer, lupus, arteriosclerosis and arthritis, among others, which bring about significant mechanical changes in the affected tissues.
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