Sclerostin: a candidate biomarker of SCI-induced osteoporosis.
Sclerostin: a candidate biomarker of SCI-induced osteoporosis.
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DOI：
10.1007/s00198-012-2072-0
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发表时间：
2013-03
影响因子：
4
通讯作者：
Battaglino, R. A.
中科院分区：
文献类型：
--
作者：
Morse, L. R.;Sudhakar, S.;Lazzari, A. A.;Tun, C.;Garshick, E.;Zafonte, R.;Battaglino, R. A.
我们评估了几种循环蛋白作为慢性脊髓损伤患者骨状态的候选生物标记物。我们报告说，在所有被测试的骨骼部位，硬化素与骨矿物质含量和骨密度显著相关。我们没有发现骨骼和任何其他被测试的生物标记物之间的联系。脊髓损伤会导致严重的骨质疏松。到目前为止，还没有发现脊髓损伤(SCI)所致骨质疏松症的循环生物标志物。我们最近报道，在慢性脊髓损伤中，循环中的硬化素与骨密度有关。在这项研究中，我们评估了几种循环蛋白作为慢性脊髓损伤男性骨骼的候选生物标记物。我们研究了39例慢性脊髓损伤患者和10例非脊髓损伤患者的骨矿含量或骨密度与下列循环骨相关蛋白的关系：硬化素、DKK-1、可溶性核因子-kappaB受体激活剂配基、护骨素、骨钙素和c-端肽。在调整了年龄后，较低的硬化素水平与所测试的所有骨骼部位较低的骨矿含量和骨密度显著相关(p=0.0002-0.03)。其他循环蛋白与骨矿含量或骨密度无关(p=0.18~0.99)。这些发现表明，循环中的硬化素反映了骨丢失的严重程度，是慢性脊髓损伤骨质疏松严重程度的候选生物标志物。
We assessed several circulating proteins as candidate biomarkers of bone status in men with chronic spinal cord injury. We report that sclerostin is significantly associated with bone mineral content and bone density at all skeletal sites tested. We found no association between bone and any other tested biomarker. Spinal cord injury results in severe osteoporosis. To date, no circulating biomarker of spinal cord injury (SCI)-induced osteoporosis has been identified. We recently reported that circulating sclerostin is associated with bone density in chronic SCI. In this study, we assessed several circulating proteins as candidate biomarkers of bone in men with chronic SCI. We assessed the relationship between bone mineral content or bone density and the following circulating bone-related proteins: sclerostin, DKK-1, soluble receptor activator of nuclear factor kappa B ligand, osteoprotegerin, osteocalcin, and c-telopeptide in 39 men with chronic SCI and 10 men with no SCI. After adjusting for age, lower sclerostin levels were significantly associated with lower bone mineral content and bone density at all skeletal sites tested (p=0.0002–0.03). No other circulating protein was associated with bone mineral content or bone mineral density (p=0.18–0.99). These findings suggest that circulating sclerostin reflects the severity of bone loss and is a candidate biomarker of osteoporosis severity in chronic SCI.
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影响因子：
4
作者：
Morse, L. R.;Battaglino, R. A.;Garshick, E.
通讯作者：
Garshick, E.
影响因子：
6.2
作者：
Li, Xiaodong;Ominsky, Michael S.;Paszty, Chris
通讯作者：
Paszty, Chris
影响因子：
2.1
作者：
Morse, Leslie R.;Giangregorio, Lora;Garshick, Eric
通讯作者：
Garshick, Eric
DOI：
10.1016/j.apmr.2005.02.006
发表时间：
2005-08-01
影响因子：
4.3
作者：
Grandas, NF;Jain, NB;Garshick, E
通讯作者：
Garshick, E
DOI：
10.1097/00002060-200207000-00006
发表时间：
2002-07-01
影响因子：
3
作者：
Kirshblum, SC;Memmo, P;Millis, S
通讯作者：
Millis, S