Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?
Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?
复制标题
DOI：
10.1007/s10539-021-09801-6
复制
发表时间：
2021
影响因子：
2.5
通讯作者：
Friston K
中科院分区：
文献类型：
--
作者：
Bhat A;Parr T;Ramstead M;Friston K
关于免疫系统在精神疾病中的作用的文献稳步增长。到目前为止，这些进展主要表现为炎症的特定方面（例如炎症标志物的血浆水平，免疫途径中的基因突变，病毒或细菌感染）与神经精神疾病（如自闭症，双相情感障碍，精神分裂症和抑郁症）的发展之间的相关性。一个基本的问题仍然悬而未决：为什么精神疾病和免疫反应交织在一起？要解决这个问题，就需要从历史上的身心二元论中退一步，这种二元论造成了这样的二分法。我们提出了三个贡献的积极推理时，解决这个问题：翻译，统一和模拟。为了说明这些贡献，我们考虑以下问题。有没有感觉衰减的免疫学类似物？大脑和免疫系统是否有一个共同的生成模型来共同优化？免疫反应和精神疾病是否都可以用自组织系统对外部环境中的威胁性刺激做出反应来解释，无论这些刺激是病原体、捕食者还是人？免疫水平上的错误推断是否会改变两个系统之间通过原则性交换在心理水平上传递的信息（反之亦然）？
There is a steadily growing literature on the role of the immune system in psychiatric disorders. So far, these advances have largely taken the form of correlations between specific aspects of inflammation (e.g. blood plasma levels of inflammatory markers, genetic mutations in immune pathways, viral or bacterial infection) with the development of neuropsychiatric conditions such as autism, bipolar disorder, schizophrenia and depression. A fundamental question remains open: why are psychiatric disorders and immune responses intertwined? To address this would require a step back from a historical mind–body dualism that has created such a dichotomy. We propose three contributions of active inference when addressing this question: translation, unification, and simulation. To illustrate these contributions, we consider the following questions. Is there an immunological analogue of sensory attenuation? Is there a common generative model that the brain and immune system jointly optimise? Can the immune response and psychiatric illness both be explained in terms of self-organising systems responding to threatening stimuli in their external environment, whether those stimuli happen to be pathogens, predators, or people? Does false inference at an immunological level alter the message passing at a psychological level (or vice versa) through a principled exchange between the two systems?
登录
查看更多内容
影响因子：
3
作者：
Campbell, John O.
通讯作者：
Campbell, John O.
DOI：
10.5402/2012/758072
发表时间：
2012-01-01
期刊：
ISRN psychiatry
影响因子：
--
作者：
Adams, D D;Knight, J G;Ebringer, A
通讯作者：
Ebringer, A
影响因子：
17.7
作者：
Bertsch, Katja;Gamer, Matthias;Herpertz, Sabine C.
通讯作者：
Herpertz, Sabine C.
影响因子：
4.6
作者：
Chen, Shih-Fen;Wang, Ling-Yi;Shen, Yu-Chih
通讯作者：
Shen, Yu-Chih
影响因子：
56.9
作者：
Buschman, Timothy J.;Miller, Earl K.
通讯作者：
Miller, Earl K.