Genetic interaction of Neuroglian and Semaphorin1a during guidance and synapse formation.
Genetic interaction of Neuroglian and Semaphorin1a during guidance and synapse formation.
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DOI：
10.1080/01677060802441380
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发表时间：
2009
影响因子：
1.9
通讯作者：
Murphey RK
中科院分区：
文献类型：
--
作者：
Godenschwege TA;Murphey RK
我们以前已经证明了神经胶质细胞和Semaphorin1a在果蝇巨纤维回路形成中的功能。这两种分子都是引导巨型纤维离开大脑所必需的，并且在巨型突触形成过程中具有不同的功能。在这项研究中，我们的特点是各种组合的神经胶质细胞和Semaphorin1a增益和功能背景的巨大纤维电路形成的损失的影响。我们发现，神经胶质细胞和Semaphorin1a基因相互作用，在轴突的指导，以及在突触形成过程中。我们的实验表明，在大脑外的巨大纤维的寻路过程中，神经胶质细胞的功能似乎依赖于Semaphorin1a。相反，在巨纤维突触形成过程中，我们观察到脑信号蛋白1a作为受体的信号传导可以被同一细胞中的神经胶质细胞改变。总之，我们的研究结果表明，神经胶质细胞和Semaphorin1a可以调节彼此的功能，在顺式和由此产生的信号输出可能是不同的指导和突触形成。
We have previously demonstrated a function for Neuroglian and Semaphorin1a in Drosophila giant fiber circuit formation. Both molecules are required for guiding the giant fibers out of the brain and have distinct functions during giant synapse formation. In this study we characterized the effects of various combinations of Neuroglian and Semaphorin1a gain and loss of function backgrounds on giant fiber circuitry formation. We found that Neuroglian and Semaphorin1a genetically interact with each other during axon guidance as well as during synapse formation. Our experiments revealed that during pathfinding of the giant fibers out of the brain, Neuroglian function seems to be dependent on Semaphorin1a. In contrast, during giant fiber synapse formation we observed that Semaphorin1a signaling as a receptor can be altered by Neuroglian in the same cell. In summary, our findings suggest that Neuroglian and Semaphorin1a can regulate each other’s function in cis and that the resultant signaling output is possibly different during guidance and synapse formation.
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影响因子：
3.5
作者：
Allen, MJ;Shan, XL;Murphey, RK
通讯作者：
Murphey, RK
影响因子：
25
作者：
Godenschwege, TA;Hu, HL;Murphey, RK
通讯作者：
Murphey, RK
影响因子：
2.5
作者：
TANOUYE, MA;WYMAN, RJ
通讯作者：
WYMAN, RJ
影响因子：
3.3
作者：
Islam, R;Kristiansen, LV;Hortsch, M
通讯作者：
Hortsch, M
影响因子：
5.3
作者：
Kamiguchi, H;Long, KE;Lemmon, V
通讯作者：
Lemmon, V