Enterovirus D68 - The New Polio?

Enterovirus D68 - The New Polio?
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DOI:
10.3389/fmicb.2018.02677
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发表时间:
2018
影响因子:
5.2
通讯作者:
Niesters HGM
Niesters HGM
中科院分区:
生物学2区
文献类型:
--
作者:
Cassidy H;Poelman R;Knoester M;Van Leer-Buter CC;Niesters HGM

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肠道病毒D68 (EV-D68)近年来出现,在世界范围内发生了大规模暴发。发病率增加的同时,临床对非脊髓灰质炎肠道病毒的认识和监测也有所提高。研究表明其嗜神经性和致病性的变化已经确定EV-D68是急性弛缓性脊髓炎(AFM)的可能病因。EV-D68的故事情节与一个世纪前的脊髓灰质炎病毒有许多相似之处,引发了EV-D68是否可以确定自己是“新型脊髓灰质炎”的讨论。提高临床医生的认识,采用适当的诊断方法,并以促进数据共享的方式将EV-D68纳入可获得的监测系统,对于揭示疾病负担至关重要。这将是防止EV-D68成为公共卫生威胁的必要步骤。
Enterovirus D68 (EV-D68) has emerged over the recent years, with large outbreaks worldwide. Increased occurrence has coincided with improved clinical awareness and surveillance of non-polio enteroviruses. Studies showing its neurotropic nature and the change in pathogenicity have established EV-D68 as a probable cause of Acute Flaccid Myelitis (AFM). The EV-D68 storyline shows many similarities with poliovirus a century ago, stimulating discussion whether EV-D68 could be ascertaining itself as the “new polio.” Increasing awareness amongst clinicians, incorporating proper diagnostics and integrating EV-D68 into accessible surveillance systems in a way that promotes data sharing, will be essential to reveal the burden of disease. This will be a necessary step in preventing EV-D68 from becoming a threat to public health.
急性弛缓性脊髓炎儿童肠道病毒 D68 感染,美国科罗拉多州,2014 年。
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