Multiple functions of endocannabinoid signaling in the brain.
Multiple functions of endocannabinoid signaling in the brain.
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DOI：
10.1146/annurev-neuro-062111-150420
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发表时间：
2012
影响因子：
13.9
通讯作者：
Freund TF
中科院分区：
文献类型：
--
作者：
Katona I;Freund TF
尽管几十年来一直被视为嬉皮士科学，但大麻素研究终于在主流神经科学中找到了当之无愧的地位。一系列突破性的发现表明，内源性大麻素分子与谷氨酸或GABA等传统神经递质一样广泛和重要，但以非常非传统的方式发挥作用。我们的目的是说明如何揭示内源性大麻素信号的分子，解剖和生理特征揭示了突触生理学中几个基本现象的新机制的见解。首先，我们总结了意想不到的进展，在分子的生物合成和失活的两种内源性大麻素，花生四烯酸和2-花生四烯酸甘油的复杂性。然后，我们展示了这些新的代谢途径是如何整合到众所周知的细胞内信号通路。这些产生内源性大麻素的信号体以阶段性和紧张性模式运作，从而差异地控制整个大脑的稳态、短期和长期突触可塑性。最后，我们讨论了细胞类型和突触特异性的内源性大麻素信号的细化可以解释大麻素的特征行为效应。
Despite being regarded as a hippie science for decades, cannabinoid research has finally found its well-deserved position in mainstream neuroscience. A series of groundbreaking discoveries revealed that endocannabinoid molecules are as widespread and important as conventional neurotransmitters like glutamate or GABA, yet act in profoundly unconventional ways. We aim to illustrate how uncovering the molecular, anatomical and physiological characteristics of endocannabinoid signaling revealed new mechanistic insights into several fundamental phenomena in synaptic physiology. First, we summarize unexpected advances in the molecular complexity of biogenesis and inactivation of the two endocannabinoids, anandamide and 2-arachidonoylglycerol. Then we show how these new metabolic routes are integrated into well-known intracellular signaling pathways. These endocannabinoid-producing signalosomes operate in phasic and tonic modes thereby differentially governing homeostatic, short-term and long-term synaptic plasticity throughout the brain. Finally, we discuss how cell type- and synapse-specific refinement of endocannabinoid signaling may explain the characteristic behavioral effects of cannabinoids.
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影响因子：
25
作者：
Gerdeman, GL;Ronesi, J;Lovinger, DM
通讯作者：
Lovinger, DM
影响因子：
4.8
作者：
Berdyshev, EV;Schmid, PC;Schmid, HHO
通讯作者：
Schmid, HHO
影响因子：
7.4
作者：
Ahn, Dong K.;Choi, Hyo S.;Mokha, Sukhbir S.
通讯作者：
Mokha, Sukhbir S.
影响因子：
25
作者：
Chavez, Andres E.;Chiu, Chiayu Q.;Castillo, Pablo E.
通讯作者：
Castillo, Pablo E.
影响因子：
5.3
作者：
Fan, Wei;Ster, Jeanne;Gerber, Urs
通讯作者：
Gerber, Urs