Evaluation of the Performance of Small Diode Pumped UV Solid State (DPSS) Nd:YAG Lasers as New Radiation Sources for Atmospheric Pressure Laser Ionization Mass Spectrometry (APLI-MS)
Evaluation of the Performance of Small Diode Pumped UV Solid State (DPSS) Nd:YAG Lasers as New Radiation Sources for Atmospheric Pressure Laser Ionization Mass Spectrometry (APLI-MS)
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小型二极管泵浦紫外固态 (DPSS) Nd:YAG 激光器作为大气压激光电离质谱 (APLI-MS) 新辐射源的性能评估
DOI：
10.1007/s13361-011-0112-1
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发表时间：
2011
影响因子：
3.2
通讯作者：
Th. Benter
中科院分区：
文献类型：
--
作者：
H. Kersten;M. Lorenz;K.J. Brockmann;Th. Benter
比较了KrF*台式准分子激光器和紧凑二极管泵浦紫外固体Nd:YAG激光器在LC-APLI质谱中作为光电离源的性能。通常应用的台式准分子激光器，工作波长为248 nm，在0.5 cm2的照射面积上提供低MW/cm2的功率密度（8 mJ/脉冲，5 ns脉冲持续时间，束腰面积0.5 cm2, 3 MW/cm2）。工作波长为266 nm的DPSS激光器提供了更高的功率密度，但照射面积却小了两个数量级（60 μJ/脉冲，1 ns脉冲持续时间，束腰面积2 × 10-3cm2, 30 MW/cm2）。在直接输注10 nM芘溶液的普通LC-APLI MS设置中，与准分子激光器相比，DPSS激光器产生的离子信号（0.9%）和信噪比（1.4%）明显更小。准分子激光对多环芳烃的低检出限（lod）为0.1 fmol， DPSS激光LC-APLI质谱在低pmol范围内的检出限是预期的。DPSS激光器在适用性（尺寸，成本，简单性）方面的优势可能使该光源成为不关注最终高灵敏度的APLI应用的首选光源。此外，根据离子接受度（DIA）测量值的空间灵敏度分布，讨论了可调离子源参数对两种激光系统性能的影响。展望了对未来应用的影响。
The performance of a KrF*bench top excimer laser and a compact diode pumped UV solid state (DPSS) Nd:YAG laser as photo-ionizing source in LC-APLI MS is compared. The commonly applied bench-top excimer laser, operating at 248 nm, provides power densities of the order of low MW/cm2on an illuminated area of 0.5 cm2(8 mJ/pulse, 5 ns pulse duration, beam waist area 0.5 cm2, 3 MW/cm2). The DPSS laser, operating at 266 nm, provides higher power densities, however, on a two orders of magnitude smaller illuminated area (60 μJ/pulse, 1 ns pulse duration, beam waist area 2 × 10–3cm2, 30 MW/cm2). In a common LC-APLI MS setup with direct infusion of a 10 nM pyrene solution, the DPSS laser yields a significantly smaller ion signal (0.9%) and signal to noise ratio (1.4%) compared with the excimer laser. With respect to the determined low detection limits (LODs) for PAHs of 0.1 fmol using an excimer laser, LODs in DPSS laser LC-APLI MS in the low pmol regime are expected. The advantages of the DPSS laser with respect to applicability (size, cost, simplicity) may render this light source the preferred one for APLI applications not focusing on ultimately high sensitivities. Furthermore, the impact of adjustable ion source parameters on the performance of both laser systems is discussed in terms of the spatial sensitivity distribution described by the distribution of ion acceptance (DIA) measurements. Perspectives concerning the impact on future APLI-MS applications are given.
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DOI：
10.1016/s1010-6030(96)04575-3
发表时间：
1997
影响因子：
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DOI：
--
发表时间：
2009
期刊：
影响因子：
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作者：
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