Rostral Anterior Cingulate Cortex-Ventrolateral Periaqueductal Gray Circuit Underlies Electroacupuncture to Alleviate Hyperalgesia but Not Anxiety-Like Behaviors in Mice With Spared Nerve Injury.
Rostral Anterior Cingulate Cortex-Ventrolateral Periaqueductal Gray Circuit Underlies Electroacupuncture to Alleviate Hyperalgesia but Not Anxiety-Like Behaviors in Mice With Spared Nerve Injury.
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头端前扣带皮层腹外侧导水管周围灰质回路是电针缓解神经损伤小鼠痛觉过敏而非焦虑样行为的基础
DOI：
10.3389/fnins.2021.757628
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发表时间：
2021
影响因子：
4.3
通讯作者：
Shao X
中科院分区：
文献类型：
--
作者：
Zhu X;Xu Y;Shen Z;Zhang H;Xiao S;Zhu Y;Wu M;Chen Y;Wu Z;Xu Y;He X;Liu B;Liu J;Du J;Sun J;Fang J;Shao X
神经病理性疼痛是慢性疼痛的常见原因，经常伴随着负面情绪，使其复杂且难以治疗。然而，这些症状背后的神经回路机制仍不清楚。在此，我们提出了一种与慢性疼痛和焦虑共病相关的新途径。利用化学遗传学方法，我们发现从嘴前扣带回(RACCGlu)到中脑导水管周围灰质(VlPAG)腹外侧部谷氨酸能投射的激活可引起假手术小鼠的痛觉过敏和焦虑样行为。抑制rACCGlu-vlPAG通路可减少备用神经损伤(SNI)小鼠的焦虑样行为和痛觉过敏；而且，电针(EA)可有效缓解这些症状。相关机制的研究表明，rACCGlu-vlPAG通路的化学激活有效地阻断了电针对SNI小鼠模型的镇痛作用，但不影响慢性疼痛诱导的负面情绪。这项研究揭示了一种新的通路，rACCGlu-vlPAG通路，它介导神经病理性疼痛和疼痛诱导的焦虑。
Neuropathic pain is a common cause of chronic pain and is often accompanied by negative emotions, making it complex and difficult to treat. However, the neural circuit mechanisms underlying these symptoms remain unclear. Herein, we present a novel pathway associated with comorbid chronic pain and anxiety. Using chemogenetic methods, we found that activation of glutamatergic projections from the rostral anterior cingulate cortex (rACCGlu) to the ventrolateral periaqueductal gray (vlPAG) induced both hyperalgesia and anxiety-like behaviors in sham mice. Inhibition of the rACCGlu-vlPAG pathway reduced anxiety-like behaviors and hyperalgesia in the spared nerve injury (SNI) mice model; moreover, electroacupuncture (EA) effectively alleviated these symptoms. Investigation of the related mechanisms revealed that the chemogenetic activation of the rACCGlu-vlPAG circuit effectively blocked the analgesic effect of EA in the SNI mice model but did not affect the chronic pain-induced negative emotions. This study revealed a novel pathway, the rACCGlu-vlPAG pathway, that mediates neuropathic pain and pain-induced anxiety.
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影响因子：
3.1
作者：
Elina, K. C.;Moon, Hyeong Cheol;Park, Young Seok
通讯作者：
Park, Young Seok
影响因子：
8.9
作者：
Gilron, Ian;Baron, Ralf;Jensen, Troels
通讯作者：
Jensen, Troels
尾部背外侧纹状体的体感皮层输入控制持续性疼痛中的共病焦虑
影响因子：
7.4
作者：
Jin, Yan;Meng, Qian;Zhang, Zhi
通讯作者：
Zhang, Zhi
影响因子：
5
作者：
Chen, QiLiang;Heinricher, Mary M.
通讯作者：
Heinricher, Mary M.
影响因子：
16.6
作者：
Frontera JL;Baba Aissa H;Sala RW;Mailhes-Hamon C;Georgescu IA;Léna C;Popa D
通讯作者：
Popa D