IDT SciTools: a suite for analysis and design of nucleic acid oligomers.

IDT SciTools: a suite for analysis and design of nucleic acid oligomers.
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IDT Scitools:用于分析和设计核酸低聚物的套件。

DOI:
10.1093/nar/gkn198
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发表时间:
2008-07-01
影响因子:
14.9
通讯作者:
Peek AS
Peek AS
中科院分区:
生物学2区
文献类型:
--
作者:
Owczarzy R;Tataurov AV;Wu Y;Manthey JA;McQuisten KA;Almabrazi HG;Pedersen KF;Lin Y;Garretson J;McEntaggart NO;Sailor CA;Dawson RB;Peek AS

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DNA和RNA寡聚体用于无数不同的生物学和生物化学实验。这些寡核苷酸被设计成具有独特的生物物理、化学和杂交特性。我们已经创建了一套完整的生物信息学工具,可以预测天然和化学修饰的核酸的性质,并协助其设计。研究人员可以选择PCR引物、探针和反义寡核苷酸,找到最适合RNA干扰的序列,计算稳定的二级结构,并评估两个序列相互作用的潜力。采用最新、最精确的热力学算法和模型。该免费软件可在http://www.idtdna.com/SciTools/SciTools.aspx上获得。
DNA and RNA oligomers are used in a myriad of diverse biological and biochemical experiments. These oligonucleotides are designed to have unique biophysical, chemical and hybridization properties. We have created an integrated set of bioinformatics tools that predict the properties of native and chemically modified nucleic acids and assist in their design. Researchers can select PCR primers, probes and antisense oligonucleotides, find the most suitable sequences for RNA interference, calculate stable secondary structures, and evaluate the potential for two sequences to interact. The latest, most accurate thermodynamic algorithms and models are implemented. This free software is available at http://www.idtdna.com/SciTools/SciTools.aspx.
DOI: 10.1073/pnas.77.11.6309
发表时间: 1980-01-01
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子: --
作者:
NUSSINOV, R;JACOBSON, AB
通讯作者: JACOBSON, AB
DOI: 10.1093/nar/gnh015
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影响因子: 14.9
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DOI: 10.1002/bip.360260911
发表时间: 1987-09-01
期刊: BIOPOLYMERS
影响因子: 2.9
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MARKY, LA;BRESLAUER, KJ
通讯作者: BRESLAUER, KJ
DOI: 10.1093/bib/3.1.87
发表时间: 2002-03-01
影响因子: 9.5
作者:
Olson, Sue A
通讯作者: Olson, Sue A
DOI: 10.1021/bi9803729
发表时间: 1998-06-30
期刊: BIOCHEMISTRY
影响因子: 2.9
作者:
Allawi, HT;SantaLucia, J
通讯作者: SantaLucia, J