Translational reprogramming in cellular stress response.
Translational reprogramming in cellular stress response.
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DOI：
10.1002/wrna.1212
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发表时间：
2014-05
影响因子：
7.3
通讯作者：
Qian, Shu-Bing
中科院分区：
文献类型：
--
作者：
Liu, Botao;Qian, Shu-Bing
细胞在不断变化的环境中生存需要适当的基因表达调控，包括翻译控制。多种应激信号通路汇聚在几个关键的翻译因子上，如eIF4F和eIF2，并在起始和延伸阶段快速调节mRNA翻译。整体蛋白质合成的抑制通常伴随着编码对细胞存活和应激恢复至关重要的蛋白质的mRNA的选择性翻译。在过去的十年中，我们对翻译重编程的理解取得了重大进展，部分原因是技术的发展，允许解剖mRNA元件和相应的结合蛋白之间的相互作用。最近使用核糖体分析的全基因组研究揭示了前所未有的蛋白质组复杂性和灵活性，通过替代翻译，提出了有趣的问题，压力诱导的翻译重编程。这些研究中出现了许多令人惊讶的发现，包括广泛的替代翻译起始，核糖体在延伸过程中的停顿，以及mRNA的可逆修饰。阐明翻译重编程的调控机制将最终导致人类疾病的新的治疗策略的发展。
Cell survival in changing environments requires appropriate regulation of gene expression, including translational control. Multiple stress signaling pathways converge on several key translation factors, such as eIF4F and eIF2, and rapidly modulate mRNA translation at both the initiation and the elongation stages. Repression of global protein synthesis is often accompanied with selective translation of mRNAs encoding proteins that are vital for cell survival and stress recovery. The past decade has seen significant progress in our understanding of translational reprogramming in part due to the development of technologies that allow the dissection of the interplay between mRNA elements and corresponding binding proteins. Recent genome-wide studies using ribosome profiling have revealed unprecedented proteome complexity and flexibility through alternative translation, raising intriguing questions about stress-induced translational reprogramming. Many surprises emerged from these studies, including wide-spread alternative translation initiation, ribosome pausing during elongation, and reversible modification of mRNAs. Elucidation of the regulatory mechanisms underlying translational reprogramming will ultimately lead to the development of novel therapeutic strategies for human diseases.
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在趋化应激后，BAG-1 IRES介导的翻译调节。
影响因子：
8
作者：
Dobbyn, H. C.;Hill, K.;Hamilton, T. L.;Spriggs, K. A.;Pickering, B. M.;Coldwell, M. J.;de Moor, C. H.;Bushell, M.;Willis, A. E.
通讯作者：
Willis, A. E.
影响因子：
9.2
作者：
Deng, J;Harding, HP;Sonenberg, N
通讯作者：
Sonenberg, N
影响因子：
14.9
作者：
Bodi Z;Button JD;Grierson D;Fray RG
通讯作者：
Fray RG
影响因子：
7
作者：
Arribere JA;Gilbert WV
通讯作者：
Gilbert WV
影响因子：
64.5
作者：
DEVER, TE;FENG, L;HINNEBUSCH, AG
通讯作者：
HINNEBUSCH, AG