A convergent functional architecture of the insula emerges across imaging modalities.
A convergent functional architecture of the insula emerges across imaging modalities.
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DOI：
10.1016/j.neuroimage.2012.03.021
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发表时间：
2012-07-16
期刊：
影响因子：
5.7
通讯作者：
Milham, Michael P.
中科院分区：
文献类型：
--
作者：
Kelly, Clare;Toro, Roberto;Di Martino, Adriana;Cox, Christine L.;Bellec, Pierre;Castellanos, F. Xavier;Milham, Michael P.
经验证据越来越多地支持这样的假设，即内在功能连接（iFC）的模式是由不同神经元网络内的诱发共激活的历史塑造的。这与iFC定义的网络和使用各种其他神经成像技术描绘的网络之间的强对应性的证据一起，表明了在多种功能和结构成像方式中可检测到的基本大脑架构。在这里，我们利用这种洞察力来研究人类大脑的功能组织。我们根据三种不同的神经成像方式-任务诱发的共激活，内在的（即，与任务无关）功能连接性和灰质结构协方差。这三种不同的基于协方差的测量结果的聚类显示了一种收敛的基本组织，这可能反映了在多个空间尺度上控制大脑结构和功能的基本大脑架构。虽然不受限制的层次，我们的包裹揭示了一个伪层次，多尺度的组织，这是一致的，与以前的聚类和荟萃分析研究的研究。最后，与每个岛屿集群相关的认知和行为领域的元分析检查阐明了广泛的功能分离可能潜在的地形观察。为了促进未来对健康和病理状态下的神经功能的研究，这里获得的岛状包可以通过http：//fcon_1000.projects.nitrc.org免费下载，沿着用于执行包的分析脚本。
Empirical evidence increasingly supports the hypothesis that patterns of intrinsic functional connectivity (iFC) are sculpted by a history of evoked coactivation within distinct neuronal networks. This, together with evidence of strong correspondence among the networks defined by iFC and those delineated using a variety of other neuroimaging techniques, suggests a fundamental brain architecture detectable across multiple functional and structural imaging modalities. Here, we leverage this insight to examine the functional organization of the human insula. We parcellated the insula on the basis of three distinct neuroimaging modalities – task-evoked coactivation, intrinsic (i.e., task-independent) functional connectivity, and grey matter structural covariance. Clustering of these three different covariance-based measures revealed a convergent elemental organization of the insula that likely reflects a fundamental brain architecture governing both brain structure and function at multiple spatial scales. While not constrained to be hierarchical, our parcellation revealed a pseudo-hierarchical, multiscale organization that was consistent with previous clustering and meta-analytic studies of the insula. Finally, meta-analytic examination of the cognitive and behavioral domains associated with each of the insular clusters obtained elucidated the broad functional dissociations likely underlying the topography observed. To facilitate future investigations of insula function across healthy and pathological states, the insular parcels obtained here have been made freely available for download via http://fcon_1000.projects.nitrc.org, along with the analytic scripts used to perform the parcellations.
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DOI：
10.1093/cercor/bhq186
发表时间：
2011-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Deen B;Pitskel NB;Pelphrey KA
通讯作者：
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DOI：
10.1176/appi.ajp.2009.08121894
发表时间：
2009-08
期刊：
The American journal of psychiatry
影响因子：
--
作者：
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通讯作者：
Milham MP
影响因子：
2.5
作者：
Adolphs, R;Tranel, D;Damasio, AR
通讯作者：
Damasio, AR
DOI：
10.1177/1073858409354384
发表时间：
2011-02
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
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作者：
Deco G;Corbetta M
通讯作者：
Corbetta M
影响因子：
9.9
作者：
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通讯作者：
Bogousslavsky, J