Relationship between cingulo-insular functional connectivity and autistic traits in neurotypical adults.
Relationship between cingulo-insular functional connectivity and autistic traits in neurotypical adults.
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DOI：
10.1176/appi.ajp.2009.08121894
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Milham MP
中科院分区：
文献类型：
--
作者：
Di Martino A;Shehzad Z;Kelly C;Roy AK;Gee DG;Uddin LQ;Gotimer K;Klein DF;Castellanos FX;Milham MP
基于对自闭症特征的维度性质的日益认识，我们使用社会反应量表成人版（SRS-A）在神经型个体中检查了其神经相关性。SRS-A测量了在一般人群中持续分布的自闭症特征。在这里，我们建立了一种新的方法来研究自闭症特征的神经基础，试图直接将SRS-A分数与观察到的前膝前扣带皮层（pgACC）的功能连接模式联系起来，该区域通常与社会认知有关。研究对象为25名正常人（26.4 ± 5.6岁），由一名在自然社会环境中认识参与者的知情人提供SRS-A，并收集其静息状态fMRI扫描结果。然后使用SRS-A作为关注的协变量进行全脑校正的连接性分析。我们发现SRS-A和pgACC功能连接与中丘脑前部之间存在显著的负相关性（Z > 2.3; p <0.05，校正）。具体而言，当前中脊神经节的相当大一部分与pgACC显示出正连接时，观察到低水平的自闭症特征。相比之下，自闭症特征的水平升高与pgACC和前中丘脑之间的负连接有关。静息状态下pgACC-PGI社交网络的功能连接与神经型成人的自闭症特征有关。需要将这种方法应用于自闭症谱系障碍样本中，以确认pgACC-前中岛叶回路是否与临床人群中自闭症特征的严重程度在维度上相关。
Based on the increased recognition of the dimensional nature of autistic traits, we examined their neural correlates in neurotypical individuals using the Social Responsiveness Scale-Adult version (SRS-A). The SRS-A measures autistic traits that are continuously distributed in the general population. Here, we establish a novel approach to examining the neural basis of autistic traits, attempting to directly relate SRS-A scores to patterns of functional connectivity observed for the pregenual anterior cingulate cortex (pgACC), a region commonly implicated in social cognition. Resting state fMRI scans were collected in 25 neurotypical individuals (26.4 ± 5.6 y) who provided SRS-A completed by an informant who knew the participant in natural social settings. Whole brain corrected connectivity analyses were then conducted using the SRS-A as a covariate of interest. We found a significant negative relationship between SRS-A and pgACC functional connectivity with the anterior portion of mid-insula (Z > 2.3; p < .05, corrected). Specifically, low levels of autistic traits were observed when a substantial portion of the anterior mid-insula showed positive connectivity with pgACC. In contrast, elevated levels of autistic traits were associated with negative connectivity between the pgACC and the anterior mid-insula. Resting state functional connectivity of the pgACC-insula social network was related to autistic traits in neurotypical adults. Application of this approach in samples with autism spectrum disorders is needed to confirm whether the pgACC- anterior mid insula circuit is dimensionally related to the severity of autistic traits in clinical populations.
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作者：
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通讯作者：
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DOI：
10.1111/j.1469-7610.2004.00266.x
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影响因子：
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社会神经科学的相关性不是Voodoo：对Vul等人的评论。 （2009）。
DOI：
10.1111/j.1745-6924.2009.01128.x
发表时间：
2009-05
期刊：
Perspectives on psychological science : a journal of the Association for Psychological Science
影响因子：
--
作者：
Lieberman MD;Berkman ET;Wager TD
通讯作者：
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